伴躯体疼痛抑郁障碍患者血清IL-6水平的对照研究

A control study on the plasma level of interleukin-6 in the depression with somatic pain symptom

目的:探讨伴躯体疼痛抑郁障碍患者血清白细胞介素-6(IL-6)水平及与躯体疼痛的相关性。方法:采用HAMD-17评估及视觉模拟评分(VAS)评估抑郁障碍患者,依据躯体疼痛症状的定义将抑郁障碍患者分为伴躯体疼痛组(疼痛组,32例)、不伴躯体疼痛组(单纯组,31例),同期入组30名健康对照组;采用ELISA法检测血清IL-6浓度。结果:1疼痛组HAMD-17总分、焦虑因子分高于单纯组[(23.4±4.0)vs(20.6±2.8),(9.4±1.7)vs(8.1±1.2))],差异均有统计学意义(t=3.297,3.627;P=0.002,0.001);2疼痛组血清IL-6浓度为(14.5±2.3)pg/ml,单纯组为(12.5±2.2)pg/ml,对照组为(11.3±2.3)pg/ml,疼痛组高于单纯组(d=2.0,P=0.001),单纯组高于对照组(d=1.2,P=0.041),差异均有统计学意义;3疼痛组血清IL-6浓度与VAS评分呈显著正相关(r=0.382,P=0.031)。结论:伴有躯体疼痛的抑郁障碍患者血清IL-6浓度较不伴躯体疼痛的抑郁障碍患者高,IL-6可能参与了抑郁障碍患者躯体疼痛症状的产生。

Objective ： To investigate the serum level of interleukin-6 （IL-6） and its influence on the so- matic pain symptom in depressed patients. Method：Hamilton depression scale（HAMD-17） and visual ana- logue scale（VAS） were used to assess depressive patients. The patients were divided into pain group （n = 30） and no pain group（ n = 31 ） according to the definition of somatic pain. The control group was 30 healthy individ- uals. The serum level of IL-6 was measured with the method of enzyme-linked Immuno-sorbent assay. Results ：①The total score of HAMD-17 and anxiety factor score in pain group were significantly higher than those in no pain group [ （23.4 ± 4.0） vs （20.6 ± 2.8）, （9.4 ± 1.7 ） vs （ 8.1 ± 1.2） ; t = 3. 297, 3. 627 ; P = 0.002,0.001 ,respe＇ctively]. ②The serum level of IL-6 was significantly higher in pain group than no pain group which was higher than the healthy controls [ （ 14.5 ± 2.3 ） pg/ml vs （ 12.5 ± 2.2 ） pg/ml, （ 12.5 ± 2.2） pg/ml vs （ 11.3 ± 2.3 ） pg/ml） ; d = 2. 0,1.2 ; P = 0.001,0.041 respectively ]. ③here was a positive relation- ship between plasma level of IL-6 and scores of VAS in depressive patients with somatic pain symptom （ r = 0. 382,P =0.031 ）. Conclusion： The serum level of IL-6 is increased in the depression with somatic pain compared with those without somatic pain,which suggest that the elevated IL-6 may be involed in the pathophys- iological mechanisms of somatic pain symptom in major depressive disorder.