不同糖耐量患者血清HSP60浓度的变化及意义

The change and significance of serum concentrations of HSP60 in patients with different glucose tolerance

目的探讨不同糖耐量患者血清热休克蛋白60(HSP60)浓度的变化及意义。方法选择90例研究对象,根据葡萄糖耐量试验(OGTT)结果分为正常对照组28例,糖尿病前期(PD)组30例,2型糖尿病(T2DM)组32例。测定其血清HSP60、空腹血糖(FBG)、空腹胰岛素(FINs)等指标,计算胰岛素抵抗指数(HOMA-IR),并对HSP60与其余指标进行相关分析。结果 PD组和T2DM组的FBG、FINs、Hb A1c、HSP60及HOMA-IR水平均高于对照组(P<0.05)。HSP60与FINs、FPG及HOMA-IR呈正相关(P<0.01)。HOMA-IR是HSP60的独立危险因素(P<0.01)。结论 HSP60可能是一个与炎症反应相关、参与糖尿病发生发展的潜在因素。随着对HSP60及糖尿病发病机制的进一步研究,HSP60可能成为预测糖尿病早期发生的一个新指标。

Objective To investigate the change and significance of serum concentrations of HSP60 in patients with different glucose tolerance.Methods 90 participants according to oral glucose tolerance test（ OGTT） were divided into 3 groups：control group with 28 participants,30 patients with prediabetes（ PD） and 32 patients with type 2 diabetes（ T2DM）.Serum HSP60,fasting blood glucose（ FBG）,fasting insulin（ FINs）,glycosylated hemoglobin（ Hb A1c） and other indicators were tested.The insulin resistance index（ HOMA-IR） were calculated and the correlation between HSP60 and the remaining indicators were analyzed.Results Compared with the control group,the levels of FPG,FINs,Hb A1 c,serum HSP60 and HOMA-IR progressive increased in PD and T2 DM group,the differences were statistically significant（ P〈 0.05）.Moreover,HSP60 was positively correlated with FINs,FPG and HOMA-IR（ P 〈0.01）.Multiple linear regression analysis indicated that HOMA-IR was the independently predictor of HSP60（ P〈 0.05）.Conclusion HSP60 might be a factor potentially involved in inflammation,and participate in the occurrence and development of diabetes.With further study of HSP60 and pathogenesis of diabetes,we hypothesized that HSP60 may become a new indicator to predict diabetes in the early stage.