盐酸氨溴索对放射性肺炎患者血清肺表面活性物质结合蛋白-A、D的影响

The effect of ambroxol hydrochloride inhalation to surfactant-associated protein-A,D in serum of patients with radiation pneumonitis

目的观察盐酸氨溴索对放射性肺炎患者血清肺表面活性物质结合蛋白-A、D(SP-A、SP-D)的影响。方法选择140例胸部恶性肿瘤接受放射治疗后出现放射性肺炎患者,随机分为对照组与观察组,各组均70例患者。对照组:给予放射性肺炎常规治疗,观察组:基础治疗同对照组,另给予盐酸氨溴索雾化吸入。采用酶联免疫吸附法(ELISA)检测患者治疗前、治疗3、6周后血清SP-A、SP-D及血清炎性因子肿瘤坏死因子-α(TNF-α)的变化。结果两组治疗3、6周后血清SP-A、SP-D水平较治疗前逐渐升高,但观察组治疗后血清SP-A、SP-D水平升高幅度低于对照组(P<0.05);治疗后3周、6周,两组患者血清TNF-α水平均有降低(P<0.05),且观察组血清TNF-α较对照组下降更显著,差异有统计学意义(P<0.05)。结论盐酸氨溴索雾化吸入能够有效促进肺泡-毛细血管屏障的修复,降低恶性肿瘤放射性肺炎患者血清SP-A、SP-D及炎性因子TNF-α的水平。

Objective To observe the effect of ambroxol hydrochloride inhalation to surfactant-associated protein-A,D in serum of patients with radiation pneumonitis.Methods One hundred and forty patients with radiation pneumonia after radiotherapy in our hospital were selected as study subjects.They were randomly divided into control group and observation group.Each group had seventy patients.The control group was given routine treatment.On the basis of routine treatment,the observation group was given ambroxol hydrochloride inhalation.Enzyme linked immunosorbent assay was used to detect the changes of serum SP-A,SP-D and serum inflammatory cytokines tumor necrosis factor alpha in patients before treatment and after 3,6 weeks.Results The serum SP-A,SP-D levels in the two groups 3,6 weeks after treatment increased gradually.But after treatment the serum SP-A,SP-D levels increased rate in the observation group was lower than that in the control group,the difference was statistically significant（ P 〈0.05）.After 3 weeks,6 weeks,the serum TNF-α levels of two groups of patients were all decreased（ P〈 0.05）,and serum levels of TNF-α in the observation group decreased more significantly than the control group,the difference was statistically significant（ P 〈0.05）.Conclusion Ambroxol aerosol inhalation can effectively promote the repair of the alveolar capillary barrier and reduce serum SP-A,SP-D and inflammatory factor TNF-alpha level in patients with malignant tumor.