参仙升脉口服液联合人工心脏起搏器对缓慢性心律失常患者生活质量影响等效性随机平行对照研究

Equivalence randomized controlled study of Shen Xian liter artificial cardiac pacemaker pulse and impact on quality of life in patients with arrhythmia

目的应用等效性随机平行对照法分析参仙升脉口服液联合人工心脏起搏器对缓慢性心律失常患者生活质量影响。方法选取从2015年1月到2015年8月入院治疗的50例缓慢性心律失常患者作为研究对象。按照入院顺序随机分为治疗组25例与对照组25例。两组患者均植入永久心脏起搏器,治疗组患者应用参仙升脉口服液治疗,对照组患者应用对照安慰剂治疗。对比两组患者治疗前后及两组患者间心室起搏频率、基础心率、电池容量、起搏电压、阻抗、阈值、脉宽和感知电流等指标变化情况,评估不同措施对于患者预后生活质量的影响。结果治疗组患者治疗后起搏器参数及心功能水平均优于对照组,差异具有统计学意义(P<0.05)。治疗组患者治疗后生活质量各指标均优于对照组,差异具有统计学意义(P<0.05)。结论临床应用参仙升脉口服液联合植入永久性人工心脏起搏器治疗缓慢性心律失常患者,可大大改善起搏器功能与降低心脏起搏率,具有延长起搏器寿命与改善患者预后的效果,临床值得广泛推广应用。

Objective Randomized parallel group equivalence analysis shenxian liter artificial cardiac pacemaker pulse and impact on quality of life in patients with arrhythmia.Methods From January 2015 to August 2015,50 patients with arrhythmia were selected as research objects,who were randomly divided into treatment group and control group,25 cases in each group.Patients were implanted a permanent pacemaker.Treatment group were treated with oral application parameters cents liter vein treatment,the control group with placebo.Ventricular pacing rate,basic heart rate,battery capacity,pacing voltage,impedance,threshold,pulse and other indicators of the current perception changes between the two groups were compared and evaluate influence of different measures on the prognosis of patients quality of life.Results After treatment,patients treated with pacemaker and cardiac function parameters levels were better than the control group,the difference was statistically significant（ P〈 0.05）.After treatment,the quality of life for each group of indicators were better than the control group,the difference was statistically significant（ P〈 0.05）.Conclusion The clinical application of Shen Xian liter pulse oral implantation of a permanent artificial heart pacemaker therapy in patients with slow arrhythmias,can greatly improve the pacemaker function and reduce cardiac pacing rate,a pacemaker prolong life and improve patients＇ Prognostic effect of clinical application should be popularized.