重组人5型腺病毒局部注射联合同步放化疗对鼻咽癌患者预后情况和肿瘤恶性程度的影响

The influence of human recombinant adenovirus type 5 local injections combined chemoradiation on the prognosis of patients with nasopharyngeal carcinoma and tumor malignant degree

目的分析重组人5型腺病毒局部注射联合同步放化疗对鼻咽癌患者预后情况和肿瘤恶性程度的影响。方法 56例鼻咽癌患者随机分为观察组及对照组各28例。对照组患者接受单纯放化疗,观察组患者接受重组人5型腺病毒局部注射联合同步放化疗。对比两组患者的治疗后肿瘤相关蛋白表达、病情相关指标、凋亡相关基因表达、复发转移相关因子水平。结果观察组患者的治疗后鼻咽局部Raf激酶抑制蛋白(RKIP)、上皮型钙黏蛋白(SE-CAD)表达量高于对照组患者,Ras基因编码的蛋白质(ras P21蛋白)、Ezrin表达量低于对照组患者(P<0.05);观察组患者的治疗后血清P-选择素(P-selectin)、血小板源性生长因子(PDGF-BB)、可溶性CD4(s CD4)、可溶性CD8(s CD8)、同型半胱氨酸(Hcy)、唾液酸(SA)值均低于对照组患者(P<0.05);观察组患者的治疗后Bcl-2、Bcl-xl表达量高于对照组患者,Bax、Bak、Bad、Bid表达量低于对照组患者(P<0.05);观察组患者的治疗后血清细胞角蛋白19片段21-1(CYFRA21-1)、EB病毒壳抗原Ig A水平(VCA-IGA)、转化生长因子-β1(TGF-β1)、恶性肿瘤特异性生长因子(TSGF)水平均低于对照组患者(P<0.05)。结论鼻咽癌患者接受重组人5型腺病毒局部注射联合同步放化疗,可以有效抑制肿瘤细胞活性,降低远期肿瘤复发及侵袭转移的能力,具有积极的临床意义。

Objective To analysis the influence of human recombinant adenovirus type 5 local injections combined chemoradiation on the prognosis of patients with nasopharyngeal carcinoma and tumor malignant degree.Methods Fifty-six patients with nasopharyngeal carcinoma according to treatment methods were divided into observation group and the control group,each group 28 cases.Control group patients receiving concurrent chemoradiation alone,observation group patients accepted human recombinant adenovirus type 5 local injections of combined chemoradiation,compared the two groups after the treatment of patients with tumor associated protein expression,disease related indicators,apoptosis related gene expression,recurrence,transfer factor levels.Results The observation group after the treatment local RKIP,SE-CAD expression quantity were higher than those of the control group patients.Ras P21,Ezrin expression amount were lower than those of the control group patients（ P 〈0.05）.In observation group after the treatment,serum P-selectin,PDGF-BB,s CD4,s CD8,Hcy,SA values were lower than those of the control group patients（ P 〈0.05）.In observation group after the treatment Bcl-2,the Bcl-xl expression quantity were higher than those of the control group.Bax,Bak,Bad,expression of the Bid amount were lower than those of the control group patients（ P〈 0.05）.In the observation group after the treatment serum CYFRA21-1,VCA IgA,TGF beta 1,TSGF levels were lower than those of the control group（ P〈 0.05）.Conclusion Human recombinant adenovirus type 5 local injections combined chemoradiation can be used in nasopharyngeal carcinoma patients.The method can effectively inhibit cancer cell activity and reduce the forward the invasion and metastasis of tumor recurrence and ability.Therefore,it has positive clinical significance.