刺激响应型介孔二氧化硅纳米粒用于肿瘤诊断治疗研究进展

Research Progress in Stimuli Responsive Mesoporous Silica Nanoparticles for Cancer Diagnosis and Therapy

参考近期相关文献,对p H、还原、温度、光、磁、生物分子等刺激响应型介孔二氧化硅纳米粒药物递送系统研究进展进行归纳总结。综述刺激响应型介孔二氧化硅纳米粒药物递送系统在肿瘤诊断治疗中的研究进展,并对其应用前景进行展望。刺激响应型介孔二氧化硅纳米粒药物递送系统可解决介孔二氧化硅纳米粒药物释放难以控制的问题,并实现肿瘤定位释药,在肿瘤诊断及治疗方面成为目前研究热点。

Referring to the recent literatures, this review summarized the recent research progress of SR-MSNDDS which were responsive to different stimulus, including pH, reduction, temperature, light, magnetic field or biomolecules, etc. To review the recent research progress of stimuli responsive mesoporous silica nanoparticle （SR-MSNDDS） drug delivery systems and predict their application prospect. SR-MSNDDS could overcome the problem of controlling drug release from MSN and achieve tumor specific drug release, which has become a research hotspot in the field of tumor diagnosis and therapy.