长沙市部分市售生鲜食品中类雌激素的含量与分布

The concentration and distribution monitoring of estrogens-like compounds in food purchased in Changsha City

目的监测长沙市市售生鲜食品中主要类雌激素(ECs)的含量,分析不同ECs含量间的关联及其在食品种类间的分布特点,为食品中ECs污染的溯源及危害控制提供基础。方法采用分层抽样方法收集食品样品172份,样品经预处理后用LC-MS/MS法同步检测壬基酚、双酚A、炔雌醇和雌二醇的含量。运用Spearman相关性分析探讨不同ECs含量间的关联,运用对应分析法探索不同ECs在各类食品中的倾向性污染特点。结果各类食品均有不同程度的目标ECs检出,172份样品的ECs检出率顺序为壬基酚94.8%(163/172)>双酚A 84.3%(145/172)>雌二醇78.5%(135/172)>炔雌醇56.4%(97/172),其中在蔬菜中的含量最高。此外,Spearman相关及对应分析结果表明双酚A与壬基酚及炔雌醇的含量呈正相关关系(P<0.05),且不同食品中主要污染的ECs种类存在差异,其中炔雌醇对谷类的污染最为严重,双酚A对水果的污染最为严重。结论单一ECs组分的含量均低于食品允许限量标准,不同ECs在食品中都有检出,且不同种类食品倾向性污染的ECs种类存在差异。

Objective To monitor the concentration and distribution of estrogens-like compounds（ ECs） in fresh food purchased in Changsha City and provide fundamental database for the pollutant traceability as well as its hazard control.Methods Abided by stratified sampling method,172 food samples were purchased randomly from markets. Bisphenol A（ BPA）,nonyl phenol（ NP）,ethinyloestradiol（ EE_2） and estradiol（ E_2） levels in food was detected by LC-MS/MS method,and the concentration relationship between different ECs compounds was analyzed by spearman correlation test. In addition,the tendency of ECs occurring in food categories was explored by correspondence analysis. Results ECs existed in all samples more or less and presented NP BPA E_2 EE_2 in detection rate. Moreover,the Spearman correlation test and correspondence analysis revealed BPA was low but positively associated with NP and EE_2 in content. Conclusion Concentration of selected ECs component in food is considerably below limitation,however,the co-existence of multiple ECs may enlarge their health effects.