血糖波动对糖尿病微血管病变的影响

Effects of glycemic variability on diabetic microvascular complications

血糖波动性是HbA1c、空腹血糖、餐后血糖以外，评估血糖控制水平的重要指标，近几年来受到越来越多的关注；连续血糖监测技术系统（CGMS）是目前最好的监测血糖波动的手段。血糖波动可能通过增加氧化应激导致2型糖尿病微血管病变的发生发展，但其和1型糖尿病微血管病变的关系尚缺乏直接临床证据。血糖波动性与糖尿病微血管病变的关系还需长期大样本前瞻性的临床研究来确证．并进行相应的基础研究来阐明其机制。

Glycemic variability, an important assessment of glycemic control in addition to HbAlc, fasting and （or） postprandial hyperglycemia, has attracted more and more attention recently. The continuous glucose monitoring system （CGMS） is the best measure of monitoring glycemic variability. Glycemic variability could enhance the oxidative stress reaction which promotes the development of microvascular complications in type 2 diabetes, while there is still a lack of direct clinical evidence in the association between glycemic variability and type 1 diabetic microvascular complications. Further long-term prospective clinical studies with large sample are warranted to investigate the relationship between glycemic variability and microvascular complications, and with the basic research, to elucidate its mechanism.