磁县2003—2012年上消化道癌发病率分析

Upper Gastrointestinal Carcinomas Incidence from 2003 to 2012 in Cixian, Hebei Province

目的分析磁县食管癌高发区10年间上消化道癌发病情况,为肿瘤防治提供依据。方法按照肿瘤登记规范,收集整理,评价上消化道癌发病情况,利用磁县登记处积累的2003—2012年登记资料,分析上消化道癌发病率的变化趋势。计算粗发病率、中国标化率和世界标化率的变化百分比,配合调整率的线性回归模型,估计发病率的年度变化百分比值(annual percent change,APC),同时分析食管癌、贲门癌、远端胃癌发病构成年度变化。结果 2003—2012年磁县上消化道癌平均粗发病率为165.36/10万,年度发病率有下降趋势;食管癌平均粗发病率为108.05/10万,年度发病率有逐年下降趋势;贲门癌平均粗发病率为31.21/10万,逐年上升趋势;远端胃癌平均粗发病率为26.10/10万,男性是上升趋势,而女性则是下降趋势。结论食管癌发病率下降明显,但仍是磁县所有恶性肿瘤发病的首位,贲门癌发病率上升明显,提示上消化道癌防治重点是加强贲门癌及远端胃癌的综合防治研究,早诊早治非常重要。

Objective To analyze the incidence of upper gastrointestinal cancers in the high incidence area of esophageal cancer in Cixian from 2003 to 2012, and to provide the evidence for the prevention and treatment of cancer. Methods Patients＇ information was collected according to malignant cancer registration standard and upper gastrointestinal carcinomas incidence was evaluated. The variation tendency of upper gastrointestinal carcinomas incidence was analyzed using registration information in Cixian registration center from 2003 to 2012. Variation rate of crude incidence rate, Chinese standardized rate and world standardized rate were calculated. Annual percent change（APC） of incidence was estimated by coordinating with adjusted rate linear regression model. At the same time, we analyzed the annual changes of esophageal cancer, gastric cardia cancer, distal gastric cancer incidence. Results The crude incidence rate of upper gastrointestinal carcinomas was 165.36/100 000 from 2003 to 2012 in Cixian, with declining tendency each year. The average crude incidence rate of esophagus cancer was 108.05/100 000, with declining tendency year by year. The average crude incidence rate of cardiac carcinoma was 31.21/100 000, with increasing tendency year by year. The average crude incidence rate of distal gastric cancer incidence was 26.10/100 000, with increasing tendency in male and declining tendency in female. Conclusion The incidence of esophagus cancer declines significantly, but it is still at the first place of malignant tumors in Cixian. The incidence of cardiac carcinoma increases obviously, suggesting that the prevention and treatment of upper gastrointestinal carcinomas should emphasize on cardiac carcinoma and distal gastric cancer. Early diagnosis and treatment are very important.