仙游县胃癌危险因素的1:2配对病例对照研究

1:2 Matched Case-control Investigation on Risk Factors of Gastric Cancer in Xianyou County

目的探讨仙游县胃癌的危险因素,为当地胃癌的防治提供依据。方法收集2013年3月—2015年7月在仙游县医院住院并经病理确诊的胃癌患者433例。按仙游县各乡镇胃癌的标化死亡率分成胃癌高、中、低发,乡镇以村为单位随机抽取健康人群,按患者的性别、年龄(±3岁)、居住地进行以人群为基础的1:2配对病例对照研究。应用条件Logistic回归进行单因素及多因素分析,计算OR值及95%可信区间。结果在控制和考虑其他混杂因素后,进食速度快、喜硬食、常吃腌菜、吸烟、有胃病史、肿瘤家族史、使用农药、对家庭现状不满意等为仙游县胃癌发病的主要危险因素;而常吃蔬菜、食用菌、牛羊肉、海带紫菜及洋葱等则为其保护因素。结论仙游县胃癌高发与多种因素尤其与当地进食腌菜饮食习惯和大量农药的使用有关,应采取综合措施降低其发病率。

Objective To explore the risk factors of gastric cancer in Xianyou County, and to provide reference for the prevention and treatment of the gastric cancer. Methods We collected 433 cases of gastric cancer which were confirmed by pathology in Xianyou Hospital of Fujian from March 2013 to July 2015. The high, medium and low incidence of gastric cancer in villages and towns were divided according to the standardized mortality rate of gastric cancer, and then took the village as a unit to select the healthy population randomly. 1：2 matched case-control investigation was based on population according to the age（±three years old）, gender and residence. The data was analyzed by conditional Logistic regression, and the OR value and 95% confidence limit were calculated. Results After controlling and considering other confounding factors, eating too fast, eating hard diet, often eating pickles, smoking, stomach disease history, family history of cancer, the use of pesticides, not satisfied with their family could increase the risk of gastric cancer in Xianyou county; and often eating vegetables, edible fungus, beef, kelp and seaweed and onion were the protect factors. Conclusion The incidence of gastric cancer in Xianyou County is related to a variety of factors, especially local eating habits of pickles and the use of pesticides, and it should take comprehensive measures to reduce the incidence of gastric cancer.