我院质子泵抑制剂在预防应激性溃疡中的合理性评价

Rationality Evaluation of the Prophylactic Use of Proton Pump Inhibitors for Stress Ulcer in Our Hospital

目的:了解大理市某医院质子泵抑制剂(PPIs)用于预防应激性溃疡(SU)的情况,评价该类药物的用药合理性。方法:抽取2015年1月神经外科、肝胆外科、普外科、骨科和泌尿外科使用PPIs的患者病历共158份,对PPIs的预防用药指征、用法用量、溶媒及疗程的合理性进行评价。结果:应用PPIs预防SU的合理率为82.91%,不合理病例总计27例,不合理率为17.09%。主要为用药指征、溶媒选择、剂量及疗程不合理,其中无指征用药占不合理用药的41.18%。结论:PPIs预防SU的应用基本合理,但不合理用药情况仍存在,还需持续改进。

Objective： To investigate the prophylactic use of proton pump inhibitors（PPIs）for stress ulcer（SU）in our hospital and to evaluate its rationality. Methods： 158 medical records of patients from Departments of Neurosurgery, Hepatobiliary Surgery, General Surgery, Orthopedics and Urology Surgery with using PPIs in January 2015 were sampled for evaluation of indications in prophylactic medication, usage and dosage, solvents and course of treatment of PPIs. Results： The reasonable utilization rate of PPIs for prevention SU was 82.91%, while 27 cases were unreasonable and the unreasonable rate was 17.09 %. The medication indications, choice of solvent, dosage and course were unreasonable, and no evidence application accounted for 41.18 % of unreasonable drug use. Conclusion： The application of PPIs in the prevention of SU is basically reasonable, but irrational use of PPIs exists, which needs to be improved.