腹腔镜辅助直肠癌根治术对患者血清中HO-1及YKL-40的影响

Effect of laparoscopic-assisted radical resection on HO-1 and YKL-40 in patients with rectal cancer

目的比较腹腔镜辅助直肠癌根治术和开腹直肠癌根治术术后血清血红素氧化酶-1(HO-1)、人类软骨糖蛋白39(YKL-40)、C反应蛋白(CRP)的变化。方法将按照纳入排除标准选取的60例直肠癌患者分为腹腔镜组(30例)和开腹组(30例),检测患者术前和术后第1、3天外周血HO-1、YKL-40、CRP水平,并进行比较分析。结果术后第1、3天腹腔镜组血清HO-1、YKL-40、CRP水平均明显低于开腹组(P<0.05);两组术后血清HO-1、YKL-40、CRP水平均较术前明显升高,且两组术后第3天血清HO-1、CRP水平较术后第1天明显升高,而YKL-40水平术后第3天较术后第1天明显下降。结论腹腔镜辅助直肠癌根治术对机体的应激反应小,且术后恢复较开腹手术快。

Objective To compare the changes of serum levels of heme oxygenase-1（HO-1）,C-reactive protein（CRP）and Chitinase-3-1ike protein 1（YKL-40）in patients with rectal cancer after laparoscopic-assisted radical operation versus open radical surgery.Methods According the integration and elimination standard,60 cases of patients with rectal cancer were selected and divided into laparoscopic group（30cases）and open group（30cases）,the concentrations of HO-1,YKL-40 and CRP in peripheral blood of patients were detected on the first and third postoperative day and preoperative day（P〈0.05）,and were compared between the two groups.Results The serum levels of HO-1,YKL-40 and CRP in the laparoscopic group were significantly lower than those in the open group on the first and third postoperative day（P〈0.05）.The serum levels of HO-1,YKL-40 and CRP were significantly increased after surgery,and serum levels of HO-1and CRP on third postoperative day were significantly increased compared with that on the first postoperative day in the two groups after surgery,while serum level of YKL-40 on the third postoperative day was significantly lower than that on the first postoperative day in the two groups after surgery.Conclusion The stress reaction is comparatively mild in patients with rectal cancer after laparoscopic assisted radical operation,and the postoperative period may be shorter in patients treated with laparoscopic assisted radical operation than those treated with open radical surgery.