慢性心力衰竭患者血清CA125与NT-proBNP表达水平及心功能的相关性研究

Correlation Study of Serum CA125 and NT-Probnp Expression Levels and Cardiac Function in Patients with Chronic Heart Failure

目的研究慢性心力衰竭(CHF)患者血清肿瘤相关抗原125(CA125)与N未端脑钠肽前体(NT-proBNP)表达水平及心功能的相关性。方法 134例CHF患者根据NYHA分级标准分为Ⅰ-Ⅱ级44例,Ⅲ级43例,Ⅳ级47例,根据原发心血管疾病分为冠心病35例,高血压性心脏病32例,扩张型心肌病34例,风湿性心脏病33例,检测和比较各组血清NT-proBNP、CA125、hs-CRP表达水平以及LVMI、LAVI、LVEF等心功能指标,同期选择40例门诊体检健康者作为研究对照组。结果 CHF组患者血清CA125、NT-proBNP、hs-CRP表达水平均明显高于对照组(P<0.05),且随着心功能程度加重而逐渐升高(P<0.05);CHF患者血清CA125、NT-proBNP表达水平依照风湿性心脏病组、高血压心脏病组、冠心病组、扩张型心肌病组顺序明显升高(P<0.05),而血清hs-CRP表达水平无明显变化(P>0.05);CHF组患者LVMI、LAVI明显高于对照组(P<0.05),而LVEF低于对照组(P<0.05),且随着心功能程度加重而逐渐升高或降低(P<0.05);血清CA125表达水平与NT-proBNP、hs-CRP表达水平以及LVMI、LAVI呈正相关性关系(P<0.05),而与LVEF呈负相关性关系(P<0.05)。结论 CHF患者血清CA125、NT-proBNP表达水平可随病情加重而明显升高,两者呈正相关性关系,且与心功能有密切的相关性。

Objective To investigate the correlation between serum CA125 and NT-proBNP expression levels and cardiac function in chronic heart failure patients. Methods 134 cases of CHF patients were divided into grade Ⅰ -Ⅱ （44 cases） , IE grade（43 cases） , Ⅳ grade （47 cases） according to NYHA standards. 134 cases of CHF patients were divided into 35 cases of coronary heart disease,32 cases of hypertensive heart disease, 34 cases of dilated cardiomyopathy and 33 cases of rheumatic heart disease according to primary cardiovascular disease. The expression levels of serum BNP,CA125 ,hs-CRP and cardiac functions such as LVMI,LAVI,LVEF were detected. 40 cases of healthy subjects were selected as the control group, at corresponding period as a control group. Results The expression levels of serum CA12 5 , NT-proBNP and hs-CRP in CHF group were significantly higher than those in control group（P 〈0. 05） ,and gradually increased as the aggravation of cardiac function（P〈0. 05）. The expression levels of serum CA125, NT-proBNP in CHF patients were significantly increased in sequential order in the patients with rheumatic heart disease group, hypertensive heart disease group, CHD group or dilated cardiomyopathy group（P 〈0. 05） , whereas the expression levels of serum hs-CRP showed no significant change（P 〉0. 05）. LVMI and LAVI in CHF group was significantly higher than those in control group（P 〈0.05） , while the LVEF in CHF group was lower than that in control group（P 〈0.05） ,and the ex-pression levels gradually increased or decreased with the degree of cardiac function（P 〈0. 05） . The expression levels of serum CA125 were positive correlated to NT-proBNP,hs-CRP and LVMI,LAVI（P 〈0. 05） ,while negatively correlated to LVEF（P 〈0. 05）. Conclusion The expression levels of serum CA125 and NT-proBNP in CHF patients were significantly increased with the aggravation of the disease, and there was a positive correlation between them,which was closely related to the cardiac function.