2型糖尿病非增生性视网膜病变抑郁症与糖化血红蛋白的关系

Type 2 Diabete Hyperplastic Retinopathy Depression and the Relationship between Glycated Hemoglobin

目的探讨T2DM非增生性视网膜(NPDR)病变抑郁症与糖化血红蛋白的关系。方法选择240例住院患者作为研究对象,以其中符合入选条件分为两组,NPDR97例;糖尿病正常眼底(NDR)对照组100例。采用汉密尔顿抑郁量表(HAMD)对入组患者进行评定。收集患者一般临床资料和化验指标,包括空腹血糖(FPG)、糖化血红蛋白(Hb Alc)等资料进行回顾性分析。结果 NPDR组Hb Alc明显高于对照组(P〈0.01),其抑郁症的发生率明显高于对照组;偏相关分析抑郁症严重程度与Hb Alc呈正相关(r=0.435 P=0.000),NPDR抑郁症患者血糖达标数为36.1%;Logistic回归分析抑郁是影响Hb Alc达标的独立危险因素(P<0.01)。结论 NPDR患者抑郁症与Hb Alc存在关联。

Objective Explore T2 DM fertile（NPDR） retinal lesions depression and therelationship between glycated hemoglobin.Methods Choose 240 cases of hospitalized patients as the research object, to which is in conformity with selected conditions can be divided into two groups,NPDR97 cases; Normal fundus（NDR）control group, 100 cases of diabetes. The Hamilton depression scale（HAMD）to assess into the group of patient.Collect patients general clinical data and laboratory test index,including fasting plasma glucose（FPG）, glycosylated hemoglobin（Hb Alc）data were retrospectively analyzed. Results Hb Alc NPDR group was obviously higher than that of control group（P〈0.01）,the incidence of depression is significantly higher than the control group; Partial correlation analysis of the severity of depression was positively correlated with Hb Alc（r=0.435 P=0.000）,NPDR depression patients blood glucose control is at target for 36.1%;Logistic regression analysis of the depression was the independent risk factors to affect Hb Alc it（P〈0.01）. Conclusion There is a connection and Hb Alc NPDR in patients with depression.