超敏肌钙蛋白I检测在糖尿病心肌损伤早期诊断中的价值

Value of high-sensitive troponin I detection in the diagnosis of early myocardial injury

目的探讨超敏肌钙蛋白I(hs-cTnI)在糖尿病心肌损伤早期诊断中的临床价值。方法选取240例2型糖尿病(T2DM)组及40例健康对照组,检测2组研究对象的糖化血红蛋白(HbA1c)、天门冬氨酸氨基转移酶(AST)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)及hs-cTnI水平。结果 T2DM组血清hs-cTnI水平显著高于健康对照组(P<0.05),血清AST、CK及CK-MB水平与健康对照组比较,差异无统计学意义(P>0.05);HbA1c≥6.5%组hs-cTnI水平及升高率显著高于HBA1c≤6.4%组(P<0.05),AST、CK、CK-MB水平及升高率在2组间差异无统计学意义(P>0.05);T2DM组HbA1c与血清hs-cTnI呈正相关(r=0.471,P<0.05)。结论 hs-cTnI诊断T2DM患者早期心肌损伤具有重要的临床价值,且hs-cTnI与HbA1c呈正相关,值得临床关注。

Objective To explore the clinical value of high-sensitive troponin I detection in the diagnosis of early myocardial injury.Methods Totally 240 type 2diabetes mellitus（T2DM）patients（study group）and 40 healthy people（healthy control group）were chosen as subjects.The serum level of HbA1 c,AST,CK,CK-MB and hs-cTnI were measured among the two groups,respectively.Results Hs-cTnI level in T2 DM group was significantly higher than in healthy control group（P〈0.05）,and AST,CK and CK-MB levels in two groups had no significant difference（P〉0.05）.Hs-cTnI level and positive rate in HbA1c≥6.5% group was significantly higher than in HbA1c≤6.4% group（P〈0.05）,and no significant difference of AST,CK and CK-MB levels and positive rate were observed in two groups（P〉0.05）.There was a positive correlation between the level of HbA1 c and that of serum hscTnI in T2 DM group（r=0.471,P〈0.05）.Conclusion The hs-cTnI level detection has important clinical value in the diagnosis of early myocardial injury in T2 DM patients,and HbA1 cis positively correlated with hs-cTnI.