丹参注射液对高血压合并左心室心力衰竭患者B型脑钠肽的影响

Effect of Danshen injections on NT-proBNP in patients with hypertension and left ventricular failure

目的探讨丹参注射液对高血压合并左室心力衰竭患者的B型脑钠肽的影响,为临床治疗提供实验室依据。方法选取2015年2月至2016年2月该院80例高血压合并左室心力衰竭患者,随机分为2组,40例患者采用常规治疗(对照组),40例患者在常规治疗的基础上增加丹参注射液(实验组)。比较2组患者治疗前后B型脑钠肽水平、炎性因子水平、临床疗效。结果治疗前,2组患者的B型脑钠肽、超敏C反应蛋白(hs-CRP)、N末端前脑利钠肽(NT-proBNP)水平差异无统计学意义(P>0.05);治疗后,实验组患者B型脑钠肽明显低于对照组(P<0.05);左心室射血分数、左心室质量指数比对照组明显升高(P<0.05);左心室容积指数比对照组显著降低(P<0.05)。实验组患者治疗后显效和总有效率明显高于对照组(P<0.05);无效率比对照组明显降低(P<0.05)。结论丹参注射液对高血压合并左心室心力衰竭患者疗效显著,明显改善患者B型脑钠肽水平,具有临床价值。

Objective To study the effect of Danshen injection on brain peptide type B（NT-proBNP）in patients with hypertension and left ventricular failure,provide an effective basis for clinical treatment.Methods Totally 80 patients of hypertension with left heart failure from February 2015 to February 2016 were randomly divided into two groups：40patients were treated with conventional therapy（control group）,40 patients in the conventional treatment combined with Danshen injection（experimental group）.We compared NT-proBNP,inflammatory factors and clinical efficacy between two groups.Results Before treatment,the expression of NT-proBNP and hs-CRP,NT-proBNP level was basically the same in two groups（P〉0.05）.After treatment,the experimental group of patients with NT-proBNP was significantly lower than the control group and the LVEF,left ventricular mass index and left ventricular volume index were significantly higher compared with the control group（P〈0.05）.The total effective rate of patients in Danshen injection groups was significantly higher（P〈0.05）.Conclusion The injection of Danshen in patients with hypertension and heart failure patients can significantly improving NT-proBNP levels and improve the cardiac function.