摘要
目的探讨艾迪注射液联合博来霉素治疗恶性胸腔积液的临床疗效。方法选取2014年1月—2015年11月榆林市第一医院收治的恶性胸腔积液患者100例,采取随机数字表法分成对照组和治疗组,每组各50例。对照组胸腔内注入注射用盐酸博来霉素,60 mg加入到40 m L生理盐水中,1次/周。治疗组在对照组基础上胸腔内注入艾迪注射液,100 m L,1次/周。两组患者连续治疗4周。观察两组的临床疗效,比较两组患者的生活质量和不良反应发生情况。结果治疗后,对照组和治疗组的总有效率分别为62.00%、84.00%,两组比较差异有统计学意义(P<0.05)。治疗后,对照组和治疗组的生活质量改善率分别为52.00%、74.00%,两组改善率比较差异有统计学意义(P<0.05)。治疗后,治疗组胸痛、发热、恶心呕吐、白细胞下降的不良反应发生率明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论艾迪注射液联合博来霉素治疗恶性胸腔积液具有较好的临床疗效,能提高患者生存质量,安全性好,具有一定的临床推广应用价值。
Objective To investigate the clinical effect of Aidi Injection combined with bleomycin in treatment of malignant pleural effusion. Methods Patients (100 cases) with malignant pleural effusion in the First Hospital of Yulin from January 2014 to November 2015 were randomly divided into control and treatment groups by digital table, and each group had 50 cases. Patients in the control group were ip injected with Bleomycin Hydrochloride for injection, 60 mg added to 40 mL normal saline, once weekly. Patients in the treatment group were ip injected with Aidi Injection (100 mL) on the basis of the control group, once weekly. After treatment, the clinical efficacies were evaluated, and quality of life and safety in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 62.00% and 84.00%, respectively, and there was difference between two groups (P 〈 0.05). After treatment, the improvement of quality of life in the control and treatment groups were 52.00%and 74.00%, respectively, and there was difference between two groups (P 〈 0.05). After treatment, the incidence of chest pain, fever, nausea, and vomiting, and white blood cell declined in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P〈0.05). Conclusion Aidi Injection combined with bleomycin has clinical curative effect in treatment of malignant pleural effusion, and can improve quality of life with good safety, which has a certain clinical application value.
出处
《现代药物与临床》
CAS
2016年第9期1455-1458,共4页
Drugs & Clinic
关键词
艾迪注射液
注射用盐酸博来霉素
恶性胸腔积液
生活质量
不良反应
Aidi Injection
Bleomycin Hydrochloride for injection
malignant pleural effusion
quality of life
adverse reaction