抗妇炎胶囊联合阿奇霉素治疗慢性宫颈炎的临床研究

Clinical study on Kangfuyan Capsules combined with azithromycin in treatment of chronic cervicitis

目的探讨抗妇炎胶囊联合阿奇霉素治疗慢性宫颈炎的临床疗效。方法选取2012年1月—2015年10月上海市松江区泗泾医院收治的慢性宫颈炎患者178例,随机分为对照组和治疗组,每组各89例。对照组患者口服阿奇霉素片,2片/次,1次/d。治疗组患者在对照组治疗基础上口服抗妇炎胶囊,3粒/次,3次/d。两组均连续治疗14 d。观察两组的临床疗效,比较两组治疗前后血管内皮生长因子(VEGF)和自然杀伤T细胞(NKTs)水平的变化情况。同时比较两组临床症状缓解时间和宫颈修复时间,随访3个月,观察两组的复发率。结果治疗后,对照组和治疗组的总有效率分别为71.91%、94.38%,两组比较差异有统计学意义(P<0.05)。治疗后,两组VEGF和NKTs水平均显著升高,同组治疗前后差异有统计学意义(P<0.05);且治疗组这些观察指标的升高程度优于对照组,两组比较差异有统计学意义(P<0.05)。治疗组临床症状缓解时间、宫颈修复时间均明显短于对照组,两组比较差异具有统计学意义(P<0.05)。随访3个月,对照组和治疗组的复发率分别为15.73%、1.12%,两组比较差异有统计学意义(P<0.05)。结论抗妇炎胶囊联合阿奇霉素治疗慢性宫颈炎具有较好的临床疗效,可加快临床症状缓解及宫颈修复,复发率低,具有一定的临床推广应用价值。

objective To investigate the clinical effect of Kangfuyan Capsules combined with azithromycin in treatment of chronic cervicitis. Methods Patients （178 cases） with chronic cervicitis in Sijing Hospital of Songjiang District in Shanghai from January 2012 to October 2015 were randomly divided into control and treatment groups, and each group had 89 cases. The patients in the control group were po administered with Azithromycin Tablets, 2 tablets/time, once daily. The patients in the treatment group were po administered with Kangfuyan Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the changes of VEGF and NKTs in two groups were compared. The remission time of clinical symptoms and cervical repair time in two groups were compared. Followed up for 3 months, the recurrence rates in two groups were observed. Results After treatment, the clinical efficacies in the control and treatment groups were 71.91% and 94.38%, respectively, and there were differences between two groups （P 〈 0.05）. After treatment, VEGF and NKTs in two groups were significantly increased, and the difference was statistically significant in the same group （P〈0.05）. And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups （P〈 0.05）. The remission time of clinical symptoms and cervical repair time in the treatment group were shorter than those in the control group, with significant difference between two groups （P〈0.05）. Followed up for 3 months, the recurrence rates in the control and treatment groups were 15.73% and 1.12%, respectively, and there were differences between two groups （P 〈 0.05）. Conclusion Kangfuyan Capsules combined with azithromycin has clinical curative effect in treatment of chronic cervicitis, and can accelerate the clinical symptoms and cervical repair, and the recurrence rate is low, which has a certain clinical application value.