糖皮质激素治疗类风湿关节炎的管理策略

Management strategy of glucocorticoid in treatment of rheumatoid arthritis

在早期类风湿关节炎中,低、中剂量的激素可以预防关节损伤,低剂量的糖皮质激素可以作为类风湿关节炎的维持治疗,中、高剂量的则可作为最初的桥方案,极高剂量或冲击疗法可用于治疗急性危及生命或累及器官的并发症。同时,激素的副作用和药物相互作用也应引起重视。

In early rheumatoid arthritis, low-moderate doses of hormones can prevent joint damage. Low-dose glucocorticoids can be used as maintenance therapy for rheumatoid arthritis, and medium and high doses may act as initial bridge program. Very high doses or pulse therapy of glucocorticoids can be used in the treatment of acute or life-threatening complications involving organs. At the same time, hormonal side effects and drug-drug interactions should draw attention.