摘要
OBJCTIVE: To compare the clinical efficacy of Traditional Chinese Medicine(TCM) to Western Medicine in the treatment of primary Sj?gren's syndrome(p SS).METHODS: We collected randomized controlled trials of TCM vs Western Medicine for the treatment of p SS in Chinese and foreign databases. The study quality was evaluated as suggested in the Cochrane Handbook. The Meta-analysis was performed using Review Manager 5.0 statistical software.RESULTS: A total of 31 randomized controlled trials with 2137 cases were retrieved. The efficiencies of TCM and control treatments were 87.18% and65.63%, respectively. The results of heterogeneity tests showed that the data were homogeneous(P = 0.83), thus a fixed effects model was used for analysis. The results revealed an odds ratio of 3.74 with a 95% confidence interval of 2.99-4.69. The overall effectiveness value was 11.48(P < 0.000 01).These results suggest the efficacy of TCM therapy for p SS better than Western Medicine.CONCLUSION: Although our findings reveal that the TCM treatment of p SS had significant advantages over its counterpart, there were some flaws in the studies included. The findings warrant further investigation.
OBJCTIVE： To compare the clinical efficacy of Traditional Chinese Medicine（TCM） to Western Medicine in the treatment of primary Sjogren＇s syndrome（p SS）.METHODS： We collected randomized controlled trials of TCM vs Western Medicine for the treatment of p SS in Chinese and foreign databases. The study quality was evaluated as suggested in the Cochrane Handbook. The Meta-analysis was performed using Review Manager 5.0 statistical software.RESULTS： A total of 31 randomized controlled trials with 2137 cases were retrieved. The efficiencies of TCM and control treatments were 87.18% and65.63%, respectively. The results of heterogeneity tests showed that the data were homogeneous（P = 0.83）, thus a fixed effects model was used for analysis. The results revealed an odds ratio of 3.74 with a 95% confidence interval of 2.99-4.69. The overall effectiveness value was 11.48（P 〈 0.000 01）.These results suggest the efficacy of TCM therapy for p SS better than Western Medicine.CONCLUSION： Although our findings reveal that the TCM treatment of p SS had significant advantages over its counterpart, there were some flaws in the studies included. The findings warrant further investigation.
基金
Supported by Grants from the National Natural Science Foundation of China(Study Icariin Improving Aging Lipid Metabolism Mechanisms Based On Nuclear Receptor PPARβand Network Pharmacology,No.81673724)
TCM Department of Chongqing Municipal Health and Family Planning Commission(Based on the Theory of"Kidney is Congenital Essence"to Study the Epigenetic Mechanisms on Preventing and Treating Lupus,No.2012-1-6.Comparative Clinical Efficacy of Clearing Heat Removing Dampness Chinese Herbal Formulations Particles and Pieces to Treat Gout,No.2012-1-16)
the Program for Introducing Talents of Chongqing Hospital of TCM(2011-001)
Chongqing Science and Technology Commission(Integration and Demonstration of Chinese Medicine Technical Characteristics on Prevention And Treatment of Rheumatism Disease,No.cstc2013jcsf10012.Study Reinforcing Kidney Sequential Therapy to Prevent and Treat Hormone Side Effects and Dependence,No.cstc2015jbky330025011)
