摘要
Although the type and etiology of cancers are different, pathways in glucose metabolism, pentose phos- phate pathway （PPP） and glutamine metabolism have been reprogrammed in cancer cells to adapt to their rapid growth and proliferation. Recent research has also shown that mul- tiple lipid metabolic pathways are altered in cancer cells. Here, we provide a brief review for the role of fatty acid metabolism in cancer development with a special focus on fatty acid uptake and de novo synthesis, triglycerides syn- thesis, storage and degradation. Reprogramming in fatty acid metabolism plays important roles in providing energy, macromolecules for membrane synthesis and lipid signals during cancer development. Understanding the mechanism of deregulated lipid metabolic pathways in cancer cells would reveal novel therapeutic approaches to combat cancer.
尽管癌症的类型和病原学是不同的，在葡萄糖新陈代谢，戊糖磷酸盐小径(PPP ) 和夫酸安新陈代谢的小径是在癌症细胞的 reprogrammed 适应他们的快速的生长和增长。最近的研究也显示出那多重类脂化合物新陈代谢的小径在癌症房间被改变。这里，我们在癌症开发为丰满的酸新陈代谢的角色向简短评论提供丰满的酸的一个特殊焦点举起和 de novo 合成， triglycerides 合成，存储和降级。在丰满的酸新陈代谢的 Reprogramming 在在癌症开发期间提供精力，为膜合成的大分子和类脂化合物信号起重要作用。理解在癌症房间的新陈代谢的小径将揭示的 deregulated 类脂化合物的机制与癌症作斗争的新奇治疗学的途径。
基金
Acknowledgments We thank members of the P.L. Laboratory at Tsinghua University for helpful discussion. This work was supported by the National Basic Research Program （2013CB530602）, and the National Natural Science Foundation of China （31430040, 31321003）.
