E3泛素连接酶Arkadia的结构特征、生物学功能及其在疾病发生发展中的作用

Arkadia:Characteristics,function and role in development of human diseases

蛋白泛素化是一种重要的转录后修饰过程,可与蛋白酶体一起识别并降解未折叠蛋白及多余蛋白.E3泛素连接酶Arkadia由RNF-111基因所编码,决定了靶蛋白底物的特异性,是泛素化过程中起决定作用的关键酶.近年来研究发现,Arkadia可以通过泛素化降解细胞内蛋白而发挥增强转化生长因子β信号通路的作用.本文回顾了Arkadia的最新研究进展,对其基本特征、生物学功能及其在疾病发生发展中的作用综述如下.

Ubiquitination of proteins is a post-translational modification that involves targeting and degrading misfolded or unwanted proteins by the proteasome. Arkadia, a RING-type E3 ubiquitin ligase also known as RNF111, confers the substrate specificity for ubiquitination and has a pivotal role in catalyzing the degradation of key signaling molecules. Recent research reveals that Arkadia plays a pivotal role in the transforming growth factor-β1 signaling pathway by catalyzing the degradation of key signaling molecules. In this review, we highlight the recent progress in understanding the characteristics, function and the role of Arkadia in the development of human diseases.