慢性阻塞性肺疾病急性加重老年住院患者呼吸道病毒感染82例分析

Analysis of respiratory virus infection condition in elderly inpatients with acute exacerbation of chronic obstructive pulmonary disease in 82 cases

目的：探讨慢性阻塞性肺疾病急性加重（AECOPD）老年住院患者呼吸道病毒感染情况。方法：采用酶联免疫吸附法对82例AECOPD患者血清标本进行病毒IgM特异性抗体进行检测。结果：45例患者病毒检测阳性,单一病毒感染27例,混合病毒感染18例。流感病毒B（IFV-B）最为多见,其次为流感病毒A（IFV-A）;IFV-B和IFV-A IgM抗体阳性率在60~69岁年龄组高于≥80岁龄组（P〈0.05）;呼吸道合胞病毒、腺病毒和副流感病毒IgM抗体阳性率在各年龄组间的差异均无统计学意义（P〉0.05）;5种病毒的性别分布及月份分布差异均无统计学意义（P〉0.05）。结论：AECOPD与呼吸道病毒感染密切相关,尤其是流感病毒,在流行季节应积极预防。

Objective：To investigate the respiratory virus infection condition in elderly inpatients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods：The serum virus-specific IgM antibody in 82 patients with AECOPD were detected by enzyme linked immunosorbent assay. Results： The positive virus IgM antibodies in 45 cases were detected, and the single virus infection in 27 cases and mixed virus infection in 18 cases were identified. The influenza B virus （IFV-B） was the most common, followed by influenza virus A （IFV-A）. The positive rates of IFV-B and IFV-A IgM antibodies in the 60 to 69 year old patients were significantly higher than those in more than 70 years old patients （ P 〈 0.05 ）. The differences of the positive rates of respiratory syncytial virus, adenovirus and parainfluenza virus IgM antibodies between different ages patients were not statistically significant（ P 〉 0.05 ）. The differences of the distributions of five respiratory viruses in different sex and month patients were not statistically significant（ P 〉 0.05 ）. Condusions：AECOPD is closely related to the respiratory virus infection, especially for influenza virus, which should be actively prevented in the epidemic season.