普瑞巴林术前给药对肛肠病患者术后疼痛的影响

Influence of preoperative administration of pregabalin on postoperative pain of patients with anorectal disease

目的探讨普瑞巴林术前给药对肛肠病患者术后疼痛及睡眠质量的影响。方法选择肛肠病手术患者60例,随机分为P组(普瑞巴林)、S组(塞来昔布)和C组为(安慰剂)。比较3组术后4、8、12、24、48 h的VAS评分、血流动力学指标及并发症情况。结果与S组和C组相比,P组在术后24 h内各个时点创口VAS评分均显著较低(P<0.01)。S组和C组术后24 h内各时点血压、心率均显著升高(P<0.05);S组和C组在术后8、12和24 h血压、心率均显著高于P组(P<0.05)。P组夜间睡眠障碍发生情况显著优于S组和C组。结论普瑞巴林超前镇痛可有效缓解肛肠病患者术后疼痛,减少应激反应,提高患者生活质量。

Objective To explore the effect of preoperative administration of pregabalin on preoperative pain and sleep quality of patients with anorectal disease. Methods A total of 60 patients with anorectal disease surgery were selected and randomly divided into group P（ pregabalin）,group S（ celecoxib） and group C（ placebo）. Wound pain score,hemodynamic indexes and complications at the time points of 8,12,24,48 hours after operation were compared among three groups.Results Compared with group S and group C,the wound VAS scores within 24 h after operation were significantly lower（ P〈0. 01）. The blood pressure and heart rate significantly increased in group S and group C within 24 h after operation（ P〈0. 05）. Blood pressure and heart rate in group S and group C were significantly higher than those in group P（ P〈0. 05） at the time points of 8,12 and 24 h after operation. The occurrence of nocturnal sleep disorder in group P was significantly better than that in group S and group C. Conclusion Pregabalin preemptive analgesia can relieve pain after surgery in patients with anorectal diseases,reduce stress,and improve the quality of life.