摘要
A novel homoisoflavone typicalvone A （1）, together with two known compounds, n-heneicosane and p-hydroxy benzoic acid, were isolated from Aspidistra typica Baill. The structure of the new compound was elucidated by sepctral techniques, viz. 1D, 2D NMR spectra and HR-ESI-MS. Compared with berberine hydrochloride, typicalvone A showed moderate anti-bacterial activities, especially against the Gram-negative Paeudomonas aeruginosa ATCC-9027 and Escherichia coli ATCC-25922, with MBC values of 1000 and 500 μg/mL, respectively. In addition, it exhibited weak inhibitory activities against the tumour cells.
本文从卵叶蜘蛛抱蛋(Aspidistra typica Baill)中分离得到一个新的高异黄酮类化合物卵叶酮A(1)及两个已知化合物正二十一烷、对羟基苯甲酸,并通过波谱技术确证其结构。卵叶酮A表现出良好的抗菌活性,其中对革兰氏阴性菌绿脓杆菌ATCC-9027和大肠杆菌ATCC-25922的抑菌效果优于盐酸小檗碱,其最小杀菌浓度分别为1000μg/mL和500μg/mL,但该化合物对肿瘤细胞增殖抑制活性不甚明显。
基金
The Project of Department of Science in Sichuan Province(Grant No.14ZA0003)
