亚砷酸联合全反式维甲酸治疗20例急性早幼粒细胞白血病的临床意义

The Clinical Significance of Arsenic Trioxide Combined With All Trans Retinoic Acid in the Treatment of 20 Cases of Acute Promyelocytic Leukemia

目的探究亚砷酸联合全反式维甲酸治疗急性早幼粒细胞白血病的临床意义。方法选取20例于2011年1月-2015年12月来我院治疗的急性早幼粒细胞白血病患者为研究对象,使用数字表法将所有患者随机分为甲乙两组,每组10例。给予甲组患者亚砷酸联合全反式维甲酸治疗,给予乙组患者亚砷酸单药治疗,对比观察两组患者临床治疗效果及不良反应发生情况。结果两组完全缓解、死亡患者及不良反应发生率比较差异无统计学意义（P〉0.05）,甲组患者完全缓解时间短于乙组（P〈0.05）。结论亚砷酸联合全反式维甲酸治疗急性早幼粒细胞白血病临床效果显著,且能有效缩短症状缓解时间。

Objective To explore the clinical significance of arsenic trioxide combined with all trans retinoic acid in the treatment of acute promyelocytic leukemia. Methods 20 cases of acute myeloid leukemia patients treated in our hospital from January 2011 to December 2015 were randomly divided into two groups,10 cases in each group. Group A were given arsenite combined with all trans retinoic acid treatment,patients of group B were given arsenite monotherapy,and the incidence of adverse reaction of two groups of patients with clinical curative effect were compared. Results There was no significant difference in the incidence of complete remission,death and adverse reactions between the two groups（P〉0.05）,the group A of patients with complete remission time was significantly shorter than that in group B（P〈0.05）. Conclusion Arsenic trioxide combined with all trans retinoic acid in the treatment of acute promyelocytic leukemia with significant clinical effect,and can effectively shorten the time of symptoms.