促性腺激素释放激素激动剂超长垂体降调节对改善子宫腺肌病患者冻融胚胎移植周期妊娠结局的价值

The Value of Gonadotropin Releasing Hormone Agonist in the Ultra Long Pituitary Down Regulation for Improving the Pregnancy Outcome of the Frozen Thawed Embryo Transfer Cycle in Patients With Uterine Gland

目的探究分析促性腺激素释放激素激动剂(GnRH-a)超长垂体降调节对子宫腺肌病患者冻融胚胎移植周期妊娠结局的改善作用。方法随机选取我院生殖医学中心子宫腺肌病患者为研究对象,根据患者在胚胎移植前是否进行GnRH-a垂体降调节,将其分为GnRH-a人工周期组(n=103)和单纯人工周期组(n=66),对比分析两组患者的妊娠结局、子宫内膜厚度、平均胚胎移植数等。结果 GnRH-a人工周期组患者黄体酮日内膜平均厚度(9.65±1.66)mm、冻融胚胎移植胚胎数目(2.02±0.66)个及妊娠率45.63%(47/103),GnRH-a人工周期组患者妊娠率与单纯人工周期组比较,差异具有统计学意义(P<0.05)。结论 GnRH-a超长调节具有改善子宫肌瘤腺肌病患者妊娠结局的优势。

Objective To explore the analysis of gonadotropin-releasing hormone agonist long pituitary down regulation of uterine adenomyosis patients improvement of pregnancy outcomes in freezing and thawing embryo transfer cycle.MethodsPatients with uterine gland disease in reproductive medicine center of our hospital were randomly selected as the research object. According to the patient before the embryo is carried out GnRH-a pituitary down regulation, which will be divided into GnRH-a artiifcial cycle group （n=103） and pure artiifcial cycle group （n=66）. The pregnancy outcome, endometrial thickness, mean embryo transfer, and so on were compared between two groups.Results GnRH-a group of patients on endometrial progesterone artificial cycle average thickness （9.65±1.66） mm, number of frozen thawed embryo transfer （2.02±0.66） and the pregnancy rate was 45.63% （47/103）. To compared with the simple artiifcial cycle group, the difference was statistically signiifcant （P〈0.05）. ConclusionGnRH-a long term regulation can improve the pregnancy outcome of patients with uterine ifbroids.