小剂量秋水仙碱联合美洛昔康胶囊治疗痛风性关节炎急性发作期的疗效与安全性分析

Analysis of Efficacy and Safety of a Small Dose of Colchicine Combined With Meloxicam Capsules for the Treatment of Acute Gouty Arthritis

目的 探究小剂量秋水仙碱联合美洛昔康胶囊治疗痛风性关节炎急性发作期的疗效与安全性。方法 选取我院2015年3月-2016年3月收治的符合标准的80例痛风性关节炎患者为研究对象,并按随机原则将其分为对照组与实验组,对照组采用秋水仙碱治疗,实验组在对照组的基础上予以小剂量秋水仙碱联合美洛昔康胶囊。治疗2周后,评价疗效及安全性,比较两组患者的临床疗效及产生的不良症状情况。结果 对照组的总有效率为62.50%,低于实验组（95.00%）,不良反应发生率（25.00%）高于实验组（5.00%）,且比较结果,差异具有统计学意义（P〈0.05）。结论 小剂量秋水仙碱联合美洛昔康胶囊治疗痛风性关节炎急性发作期的疗效显著。

Objective A small dose of colchicine combined with Meloxicam Capsules to explore the effcacy and safety of the treatment of acute attack of gouty arthritis.Methods 80 cases of gout arthritis patients treated in our hospital from March 2015 to March 2016 were selected as the research object and divided into control group and experimental group according to the principle of random. Control group were treated with colchicines, experimental group, on the basis of the control group, was given small dose of colchicine combined with meloxicam capsules, evaluation of efficacy and safety after 2 weeks of treatment, the clinical effcacy of the two groups were compared and the adverse conditions were compared.Results The total effective rate of the control group （62.50%） was lower than that of experimental group （95%）, the incidence of adverse reactions （25.00%） was higher than that of the experimental group （5.00%）, and the difference was statistically signiifcant （P 〈 0.05）. Conclusion A small dose of colchicine combined with meloxicam capsules in the treatment of acute exacerbation of the effects of gouty arthritis.