拉坦前列素联合马来酸噻吗洛尔的降眼内压效果观察

Observation on the Effect of Latanoprost Combined With Timolo Maleate for Patients With High Intraocular Pressure

目的：观察分析拉坦前列素联合马来酸噻吗洛尔与单用拉坦噻吗滴眼液治疗高眼内压的降眼压效果，并分析其药物依从性和安全性。方法80例高眼内压病例为2014年10月～2015年10月收治，遵循随机分组原则分为观察组（n=40）和对照组（n=40），对照组患者仅给予拉坦噻吗滴眼液治疗，观察组采用马来酸噻吗洛尔联合拉坦前列素治疗，观察患者降眼压效果、药物依从性、安全性。结果两组治疗后6个月降眼压效果比较差异无统计学意义（P＞0.05）；观察组不良反应发生率12.50%，与对照组的15.00%比较，差异无统计学意义（P＞0.05）；观察组药物依从性为47.53%，低于对照组的65.63%，两组比较，差异有统计学意义（P＜0.05）。结论采用拉坦前列素联合马来酸噻吗洛尔与单用拉坦噻吗滴眼液疗效相当，安全性较高，但单用拉坦噻吗滴眼液的药物依从性更好。

Objective To observe and analyze the effect of latanoprost combined with timolol maleate and single latanoprost and timolol maleate eye drops for patients with high intraocular pressure, and analyze its drug compliance and safety.Methods 80 cases of high intraocular pressure and who accepted treatments from October 2014 to October 2015 were divided into observation group （n=40） and control group （n=40） according to the principle of random grouping. The control group was only given latanoprost and timolol maleate eye drops treatment while the observation group was given the latanoprost combined with timolol maleate treatment. then, the lowering intraocular pressure, drug compliance, safety of patients were observed.Results There was no significant difference in effect of lowering intraocular pressure between the two groups after treatment for 6 months（P〉0.05）. The adverse reaction rate in the observation group was 12.50%, the control group was 15.00%, and two groups were compared, the difference was not statistically signiifcant （P〉0.05）. The drug compliance in the observation group was 47.53%, which was signiifcantly lower than that in the control group of 65.63%, two group were compared （P〈0.05）. Conclusion The clinical effects of latanoprost combined with timolol maleate are equal to the single latanoprost and timolol maleate eye drops, which the safety is high, but the drug compliance of single latanoprost and timolol maleate eye drops are better.