期刊文献+

应用SOX方案与EOF方案治疗晚期胃癌的临床疗效比较

Clinical Observation on SOX and EOF in Treatment of Patients With Advanced Gastric Cancer
下载PDF
导出
摘要 目的:本研究主要比较SOX方案与EOF方案治疗晚期胃癌的临床疗效及不良反应。方法回顾性选取2012年1月~2015年12月我院收治的80例晚期胃癌患者,分为SOX方案组40例与EOF方案组40例,两组均化疗两周期后分析其临床疗效及毒副反应。结果两组方案有效率(CR+PR)比较,差异无统计学意义(P>0.05),SOX方案组骨髓抑制、胃肠道反应轻于EOF方案组(P<0.05),其他肝肾功能损害、神经毒性等,两组差异无统计学意义(P>0.05)。结论 SOX方案和EOF方案治疗晚期胃癌的近期疗效相同,但SOX方案不良反应发生率较低,在化疗毒副反应方面更易为患者接受。 Objective To evaluate the clinical effect and adverse reaction of SOX versus EOF in the treatment of advanced gastric cancer.Methods 80 patients with advanced gastric cancer from January 2012 to December 2015 were divided into SOX group and EOF group. After treatment, the clinical effects and adverse reaction were elvaluated.Results Between the two groups, there was no signiifcant difference in total effciency rate(P〉0.05). In the SOX group, the bone marrow suppression and gastrointestinal reaction were less than that of the EOF group (P〈0.05). There was no signiifcant difference between the two groups in liver and kidney function damage and neurotoxicity (P〉0.05).Conclusion SOX regimen and EOF regimen in the treatment of patients with advanced gastric cancer has the same curative effect. However, the incidence of adverse reactions of SOX is low, and it is more easy to be accepted by patients in chemotherapy.
作者 孙颖
出处 《中国继续医学教育》 2016年第29期160-161,共2页 China Continuing Medical Education
关键词 晚期胃癌 SOX EOF 有效率 Advanced gastric cancer, SOX, EOF, Effective rate
  • 相关文献

参考文献4

二级参考文献21

  • 1王竞,王金万.胃癌治疗进展[J].癌症进展,2004,2(2):88-93. 被引量:37
  • 2陈智伟,廖美琳.RECIST标准在肿瘤治疗疗效评价中的应用[J].中国肿瘤,2004,13(10):616-618. 被引量:175
  • 3KatherineDCrew,AlfredINeugut.Epidemiology of gastric cancer[J].World Journal of Gastroenterology,2006,12(3):354-362. 被引量:189
  • 4Cunningham D,Allum WH,Stenning SP,菅鑫妍.手术期间化学疗法与单独手术治疗可切除的胃食管癌疗效比较[J].中国处方药,2006,5(8):59-60. 被引量:434
  • 5鄢践.实体瘤疗效评定最新指南[J].国外医学·肿瘤分册,2000,27(6):375-375.
  • 6Persiani R, DUgo D, Rausei S, et al. Prognostic indicators in locally advanccd gastric Cancer(LAGC)treated with preoperative chemotherapy and D2 gastrectomy[J]. J Surg Oned, 2005,89 (4) : 227-236.
  • 7Jemal A, Thomas A, Murray T, et al. Cancer statistics, 2002 [J]. CA Cancer J CIin, 2002,52( 1 ) : 2347.
  • 8Elliot Newman E, Marcus S G, Potmesil M, et al. Neoadjuvant chemotherapy with CPT-I1 and cisplatin downstages locally advanced gastriccancer [ J ]. J Gastrointest Surg, 2002,6 (2) : 212-223.
  • 9Kim D Y, Kim J H, Lee S H, et al. Phase II study of oxaliplatin, 5-fluorouracil and leucovorin in previously platinum-treated patients with advanced gastric cancer [J]. Ann Oncol, 2003,14(3) : 383-387.
  • 10中国抗癌协会.新编常见恶性肿瘤诊治规范(合订本)[M].北京:中国协和医科大学出版社,1991.7-9.

共引文献143

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部