应用SOX方案与EOF方案治疗晚期胃癌的临床疗效比较

Clinical Observation on SOX and EOF in Treatment of Patients With Advanced Gastric Cancer

目的：本研究主要比较SOX方案与EOF方案治疗晚期胃癌的临床疗效及不良反应。方法回顾性选取2012年1月～2015年12月我院收治的80例晚期胃癌患者，分为SOX方案组40例与EOF方案组40例，两组均化疗两周期后分析其临床疗效及毒副反应。结果两组方案有效率（CR＋PR）比较，差异无统计学意义（P＞0.05），SOX方案组骨髓抑制、胃肠道反应轻于EOF方案组（P＜0.05），其他肝肾功能损害、神经毒性等，两组差异无统计学意义（P＞0.05）。结论 SOX方案和EOF方案治疗晚期胃癌的近期疗效相同，但SOX方案不良反应发生率较低，在化疗毒副反应方面更易为患者接受。

Objective To evaluate the clinical effect and adverse reaction of SOX versus EOF in the treatment of advanced gastric cancer.Methods 80 patients with advanced gastric cancer from January 2012 to December 2015 were divided into SOX group and EOF group. After treatment, the clinical effects and adverse reaction were elvaluated.Results Between the two groups, there was no signiifcant difference in total effciency rate（P〉0.05）. In the SOX group, the bone marrow suppression and gastrointestinal reaction were less than that of the EOF group （P〈0.05）. There was no signiifcant difference between the two groups in liver and kidney function damage and neurotoxicity （P〉0.05）.Conclusion SOX regimen and EOF regimen in the treatment of patients with advanced gastric cancer has the same curative effect. However, the incidence of adverse reactions of SOX is low, and it is more easy to be accepted by patients in chemotherapy.