放疗后肉瘤患者的临床病理观察及文献复习

After Radiotherapy in Patients with Sarcoma: Clinicopathological Study and Literature Review

目的探讨放疗后肉瘤的临床病理特点、发病机制、治疗方法和预后。方法回顾性分析2例放疗后肉瘤患者的临床资料,并结合国内外文献进行复习。结果 2例患者术后均曾行规范化放射治疗,分别于治疗后9年和8年出现放射治疗野内的第2原发恶性肿瘤,病理类型均为软组织肉瘤。结论放射后肉瘤是放射治疗的一种少见而严重的并发症,恶性程度高,预后差。对于曾有放射治疗史,单纯在放射治疗野内出现的肿瘤,应警惕可能发生放射治疗诱发的肉瘤。

Objective To investigate the clinicopathologic features, the mechanism of postradiation sarcoma, and to discuss its treatment and progonosis. Methods 2 cases of postradiation was reported and literatures were reviewed. Results Both cases underwent adjuvant or definitive radiotherapy, and sarcomas occurred after nine years and eight years respect. The histological types were sacomas of soft tissues. Conclusions Postradiation sarcoma is a secondary tumor as a result of radiation therapy and is a rare but high malignant disease and often has poor prognosis. A neoplasm, with the previously radiated area, points out the possibility of carcinogenesis of radiation-associated sarcoma.