舌下含服粉尘螨滴剂治疗季节性过敏性结膜炎疗效观察

Sublingual administration of dermatophagoides farinae drops for seasonal allergic conjunctivitis-a prospective clinical study

目的探讨舌下含服粉尘螨滴剂治疗季节性过敏性结膜炎的临床疗效。方法选择2012年1月至2016年4月在我院接受治疗的156例季节性过敏性结膜炎患者,按照随机数字法分为实验组与对照组,对照组予以色甘酸钠滴眼液治疗,实验组予以舌下含服粉尘螨滴剂治疗,比较两组患者眼部综合症状评分、主要症状体征改善时间及临床疗效。结果治疗前两组患者眼部综合症状评分表,差异无统计学意义(P>0.05);经相应的治疗后实验组3、12、24个月的眼部综合症状评分均低于对照组,比较差异均具有统计学意义(P<0.05)。治疗后两组患者对症用药评分均有不同程度的改善,差异具有统计学意义(P<0.05),且实验组患者对症用药评分低于对照组,比较差异具有统计学意义(P<0.05)。实验组近期总有效率为93.59%,显著高于对照组82.05%的总有效率,比较差异均具有统计学意义(P<0.05)。两组患者均未出现严重不良反应。结论舌下含服粉尘螨滴剂治疗季节性过敏性结膜炎可改善患者的眼部综合症状,提高治疗效果,减少了激素及抗组胺类药物的应用。

Objective To investigate the effect of sublingual dermatophagoides farinae drops administration on the treatment of seasonal allergic conjunctivitis.Methods From January 2012 to April 2016 we treated 156 cases of seasonal allergic conjunctivitis.Patients received sublingual dermatophagoides farinae drops or cromolyn eye drops as control.We studied the differences in ocular symtopms and signs between the two groups.Results Ocular symptom score was not dif-ferent between the two group of patients before treatment.After treatment, symptoms improved in both groups of patients. At 3, 12, and 24 months, patients treated with sublingual dermatophagoides farinae drops felt significantly better than those who were treated with cromolyn eye drops （ P 〈0.05）.Overall effective rate was 93.59%in patients treated with sublin-gual dermatophagoides farinae drops, while it was 82.05%in control group （ P 〈0.05）.There was no serious adverse re-actions in either group.Conclusions Sublingual dermatophagoides farinae drops could improve eye symptoms in allergic patients.This treatment also could reduce the use of steroids and anti-histamine drugs.