甘露糖结合凝集素2基因P52位点多态性与结核病易感性关系的Meta分析

Association between Mannose-binding Lectin 2 Codon 52 A/D Gene Polymorphism and Tuberculosis Risk:a Meta-analysis

目的应用Meta分析方法评价甘露糖结合凝集素2(MBL 2)基因P 52位点多态性与结核病易感性的关系。方法计算机检索中英文数据库Pub Med、中国期刊全文数据库、中国生物医学文献数据库、维普数据库、万方数据库等,查找各数据库从建库至2015年5月20日公开发表的关于研究MBL 2基因多态性与结核病易感性关系的相关文献。由2名评价者根据纳入与排除标准筛选文献,提取并评价文献资料后,采用Rev Man 5.2软件及Stata 10.0软件进行Meta分析。结果最终共纳入9个病例对照研究,其中包括结核病组1 282例,对照组1 483例,经异质性检验,各研究间存在统计学异质性(P<0.10),故总体分析采用随机效应模型。Meta分析结果显示:显性模型(DD+AD vs.AA)中,对于总体人群而言,MBL 2基因P 52位点与结核病易感性关联无统计学意义[OR=1.46,95%CI(0.87,2.43),P=0.15];但根据种族进行亚组分析时,在亚洲人群中,MBL 2基因P 52位点与结核病易感性关联有统计学意义[OR=1.96,95%CI(1.27,3.03),P=0.003],在高加索人群中,MBL 2基因P 52位点与结核病易感性关联无统计学意义[OR=1.36,95%CI(0.52,3.56),P=0.53]。结论在亚洲人群中,MBL 2基因P 52位点可能是增加结核病患病风险的危险因素,在高加索人群中,MBL 2基因P 52位点多态性与结核病的发病风险可能不存在相关性。

Objective To investigate the relationship between the mannose-binding lectin 2（MBL 2） codon52 A/D gene polymorphism and tuberculosis risk by meta-analysis.Methods The Embase,PubMed,China National Knowledg Infrastructure,Wanfang databases were searched to identify domestic and foreign case-control studies involving the association between MBL 2 codon 52 A/D gene polymorphism and tuberculosis risk from establishment of these database till May 20,2015.Two reviewers collected data according to the inclusion and exclusion criteria,and extracted data and assessed quality of the literature.Meta analysis was performed by RevMan 5.2 software and Stata 10.0software.Results In total,1 282 cases and 1 483 controls from nine case-control studies were included in this metaanalysis.According to the test of heterogeneity,there was statistical heterogeneity among these studies（P〈0.1）.Thus,we conducted the analysis by the random effect model on the basis of heterogeneity test.The results indicated that MBL 2codon 52 A/D gene polymorphism might not be associated with risk of tuberculosis[DD＋AD versus AA：OR=1.46,95%CI（0.87,2.43）,P=0.15]in total analysis by random effect model.However,when stratifying separately according to ethnicity,a significant association between MBL 2 codon 52 A/D gene polymorphism and tuberculosis risk was found in Asians[OR=1.96,95%CI（1.27,3.03）,P=0.003 for DD＋AD versus AA],but not among Caucasians[OR=1.36,95%CI（0.52,3.56）,P=0.53 for DD＋AD versus AA].Conclusions The present meta-analysis indicates that the polymorphism of MBL 2 codon 52 A/D may be a risk factor for TB in Asians.But the MBL 2 codon 52 A/D gene polymorphism may not contribute to the risk of tuberculosis in Caucasians.