非酒精性脂肪性肝病与幽门螺杆菌的相关性研究

Research on the Correlation between Nonalcoholic Fatty Liver Disease and Helicobacter pylori

目的初探非酒精性脂肪性肝病（NAFLD）与幽门螺杆菌（HP）感染之间的关系。方法收集2015年3月-6月在健康管理中心同时行碳14-尿素呼气试验及腹部彩色多普勒超声检查的健康检查者的体检数据,采用横断面研究方法,将符合纳入标准的人群分为NAFLD组和正常对照组,比较两组间HP感染情况,同时应用logistic回归分析HP感染与NAFLD的关系。结果 NAFLD组男性所占比例、年龄、体质量、体质量指数（BMI）、腰围、谷丙转氨酶（ALT）、谷草转氨酶、谷氨酰转肽酶、白蛋白、空腹血糖（GLU）、总胆固醇、三酰甘油（TG）、低密度脂蛋白胆固醇、血压均明显高于对照组;NAFLD组的身高、高密度脂蛋白胆固醇低于对照组,差异均有统计学意义（P〈0.05）。男性人群的NAFLD阳性检出率高于女性。不同年龄段NAFLD患者的检出率比较差异有统计学意义（P〈0.05）,50-59岁NAFLD阳性率最高。男性人群的HP阳性检出率与女性比较差异无统计学意义（P〉0.05）,不同年龄段HP感染者的检出率比较差异也无统计学意义（P〉0.05）。在18-29岁、30-39岁、40-49岁、50-59岁、70-79岁年龄段中,NAFLD组HP阳性率高于对照组,差异有统计学意义（P〈0.05）。logistic回归分析表明年龄、HP感染、TG、ALT、BMI、GLU、舒张压均与NAFLD密切相关（P〈0.05）。结论 HP感染可能是NAFLD发生的危险因素。

Objective To investigate the relationship between nonalcoholic fatty liver disease（NAFLD） and Helicobacter pylori（HP） infection.Methods Medical examination data of healthy physical examination participates who underwent carbon 14 urea breath test for detection of HP and abdominal ultrasound examination between March and June 2015 were analyzed.Cross sectional analysis was carried out.Based on the diagnostic criteria of NAFLD,the subjects were divided into two groups：NAFLD group and normal control group.HP infection was compared between the two groups.Logistics regression analysis was performed to analyze the relationship between HP infection and NAFLD.Results The proportion of men,age,weight,body mass index（BMI）,waistline,alanine aminotransferase（ALT）,aspartate aminotransferase,glutamyl transferase,albumin,fasting blood-glucose（GLU）,total cholesterol triacylglycerol（TG）,low density lipoprotein-cholesterol,and blood pressure were all significantly higher in the NAFLD group than the control group（P〈0.05）,while height and high density lipoprotein-cholesterol were significantly lower in the NAFLD group（P〈0.05）.The detection rate of NAFLD in males was higher than that in females.The detection rates of NAFLD in different age groups were significantly different,and the highest detection rate of NAFLD was in the age group of 50-59 years old（P〈0.05）.The rate of HP infection was not significantly different in subjects of different ages and genders（P〈0.05）.The rate of HP infection in the NAFLD group was significantly higher than those of the control group in age groups of 18-29,30-39,40-49,50-59,and 70-79 years old（P〈0.05）.The logistic regression analysis revealed that age,HP infection,TG,ALT,BMI,GLU,and diastolic pressure were correlated with NAFLD（P〈0.05）.Conclusion HP infection may be a risk factor in the development of NAFLD.