离体肺灌注技术在肺移植中的应用进展

Progress of Clinical Application for Ex Vivo Lung Perfusion in Lung Transplantation

肺移植(lung transplantation,LTx)已经成为药物或外科手术无法治疗的终末期肺疾病的标准治疗方式。目前符合标准的供体肺数目已经无法满足移植需求,造成部分患者在等待供肺的过程中死亡。目前可改善供肺短缺现状的方法中,离体肺灌注(ex vivo lung perfusion,EVLP)是应用于肺移植领域一种延长供肺保存时间和修复供肺损伤的技术。EVLP可以即时评估供体肺功能,为药物甚至基因治疗提供平台,改善"边缘供肺"(marginal donor lungs)功能,增加了符合移植条件移植肺的数量,在一定程度上缓解了供肺缺乏的现状。本文就EVLP在肺移植领域中的临床应用及研究进展做一综述。

Lung transplantation has been a standard treatment option for patients with end-stage lung disease. However, the demand for donor lungs exceeds the poor of available organs, resulting in considerable waiting list mortality. Among all the useful methods so far, ex vivo lung perfusion （EVLP） has been considered a useful technique in lung transplantation, which helps prolong donor lung preservation and repair donor lung in）uries. Current studies have demonstrated EVLP can evaluate the donor lung function continuously and provide platform for pharmaceutical or even gene therapy. Moreover, EVLP improves the function of marginal donor lungs and increases the quantity of lungs meeting the transplant criteria, which could extend the donor pool. This article reviews the clinical application and research progress of EVLP in lung transplantation.