血管中膜钙化的机制

The mechanisms of medial vascular calcification

血管钙化是一个主动的、可逆转的并且受到高度调控的病理过程,其特点是羟磷灰石结晶沉积于血管系统。血管钙化可分为血管内膜钙化和血管中膜钙化等。血管中膜钙化常见于糖尿病、慢性肾功能衰竭及衰老的血管中。本文主要综述了血管中膜钙化的相关机制。

Vascular calcification is an active, invertible and highly regulated pathophysiological process, characterized by the deposi- tion of hydroxyapatite crystal in vascular wall. Vascular calcification is classified into two types based on the sites of calcification： intimal atherosclerotic calcification and MOnckeberg＇s medial calcification. Medial vascular calcification is a pathological phenomenon commonly existed in diabetes, chronic kidney failure and aging. The current review summarizes the mechanisms of medial vascular calcification.