摘要
目的探讨白介素17(IL-17)对鼻咽部恶性黑色素瘤血管生成的影响。方法以收治的鼻咽部恶性黑色素瘤患者21例为研究对象,作为观察组,以同期的21例健康体检者作为对照组,分析两组外周血清IL-17、血管内皮生长因子(VEGF)表达水平及鼻咽部恶性黑色素瘤患者血清IL-17、VEGF表达水平与肿瘤组织微血管密度(MVD)的相关性。结果观察组外周血清IL-17、VEGF表达水平均高于对照组,差异均具有统计学意义(P﹤0.01);观察组外周血清IL-17与VEGF表达水平呈正相关(P﹤0.01)。鼻咽部恶性黑色素瘤患者血清IL-17、VEGF表达水平与MVD均呈正相关(P﹤0.01)。结论 IL-17可能通过上调VEGF的表达,在鼻咽部恶性黑色素瘤血管生成过程中起重要作用。
Objective To investigate the effect of interleukin-17 （IL-17） on the angiogenesis of malignant melanoma of nasopharynx. Method 21 cases of malignant melanoma of nasopharynx were enrolled as study group, and 21 healthy adults were included as control group. IL-17, vascular endothelial growth factor （VEGF） in peripheral blood in two groups were detected, and correlation between IL-17, VEGF levels and microvessel density （MVD） in patients with ma-lignant melanoma of nasopharynx were analyzed. Result Levels of IL-17, VEGF in study group were significantly high-er than those of the control group, with significant differences observed （P〈0.01）;IL-17 levels were positively correlated with VEGF expression in study group （P〈0.01）. The serum IL-17, VEGF levels were positively correlated with MVD in patients with malignant melanoma of nasopharynx （P〈0.01）. Conclusions VEGF may be upregulated by IL-17, which plays an important role in the angiogenesis of malignant melanoma of nasopharynx.
出处
《癌症进展》
2016年第8期761-763,共3页
Oncology Progress
