胃癌及癌前疾病与血清胃泌素17的测定及其他影响因素研究

Serum gastrin 17 and other factors influencing gastric cancer and precancerous disease

目的探讨血清胃泌素17(G17)水平与胃癌及癌前病变的关系。方法选择130例胃部疾病患者,采用酶联免疫吸附测定法(ELISA)对患者血清G17水平进行检测,并进行幽门螺杆菌Ig G(HP-Ig G)抗体滴度检测。分析血清G17水平的临床检测价值及与胃癌发生的关系。结果年龄﹥60岁,HP-Ig G检测阴性,患有萎缩性胃炎(AG)以及胃癌(GC)患者,女性血清G17高于男性患者,差异具有统计学意义(P﹤0.05);GC、胃黏膜糜烂(GE)以及胃溃疡(GU)患者G17水平高于浅表性胃炎(SG)患者;对于HP-Ig G检测阴性患者,GU、GC患者G17含量高于SG患者;AG、GE、GC及GU患者G17含量高于浅表性胃炎合并糜烂(SG-IM)患者;GU患者G17含量高于异型增生(GD)患者,差异均具有统计学意义(P﹤0.05)。结论不同胃疾病患者血清G17含量会受到性别以及HP-Ig G感染情况等多种因素影响。患者血清G17含量能够有效作为胃癌疾病的生物标志物,在进行胃癌疾病筛查的过程中发挥一定的价值,为疾病的临床治疗提供准确的参考依据。

Objective To explore the correlation between serum gastrin 17 （G17） and the gastric cancer and precan-cerous lesion. Method 130 cases of patients with stomach diseases were enrolled in the study, and the enzyme-linked im-munosorbent assay （ELISA） was utilized to determine the serum level of G17 of all patients, besides, the titer of helico-bacter pylori IgG （HP-IgG） antibody in all patients was also detected. Result For patients aged〉60 years, with negative HP-IgG, and atrophic gastritis （AG） or gastric cancer （GC）, higher level of serum G17 was observed in females compared with that in males, with significant differences observed （P〈0.05）; Patients with GC, gastric mucosal erosion （GE） and gastric ulcer （GU） had higher serum G17 than those with superficial gastritis （SG） （P〈0.05）;In patients with negative HP-IgG, those who with GU or GC were of higher level of G17 than that those with SG;And those with AG, GE, GC or GU were with more serum G17 than those with SG-IM;While higher G17 was observed in patients with GU than those with GD （P〈0.05）. Conclusion For patients with varied digestive diseases, of which the serum level of G17 is subjected to the mediating of patient’s gender and HP-IgG status. Patient’s blood serum level of G17 is an appropriate biomarker of gastric cancer, which is predictive in the process of screening for gastric cancer diseases, providing accurate reference ba-sis for clinical treatment of disease.