mTOR通路参与多囊卵巢综合征胰岛素抵抗的病理生理改变

Mammalian target of rapamycin signaling is involved in the pathophysiological changing of insulin resistance in polycystic ovary syndrome

胰岛素抵抗(IR)是多囊卵巢综合征(PCOS)发病的重要病理生理基础,雷帕霉素靶蛋白(mTOR)通路过度激活可导致IR,为PCOS患者多种细胞IR的机制之一。PCOS患者体内高雄激素环境也通过mTOR通路加重细胞IR。高胰岛素血症促进卵巢雄激素的合成,增多的雄激素加重全身细胞IR。卵巢细胞同样存在IR,mTOR通路在其中的作用有待进一步挖掘。

Endometrial receptivity （ER） has important effects on blastocyst implantation. Existing study indicates that the endometrium of recurrent spontaneous abortions （RSA） has superfertile compared with normal women of childbearing age. And the superfertile maybe results in the decrease of endometrial＇s ability to select the superior embryo, then affect the pregnancy outcome. There are a variety of evaluation indexes for ER in clinic, the widely applied indexes nowadays are ultrasound, morphologic, molecular biological parameters, hormone traits, endometrial telomerase activity and gene markers. Ultrasound examination can make an easy and efficient forecast of ER, however, with the more controversy. Pinopode can be used as the evaluation index of ER, because the detection method is traumatic, therefore, it has not been applied in clinic. Molecular biological parameters, hormone traits and endometrial telomerase activity have unique clinical application values for the evaluation of ER. However, gene research introduces an eatirely new area for the ER research.