咽喉反流与慢性鼻-鼻窦炎

Laryngopharyngeal reflux and chronic rhinosinusitis

胃食管反流（gastroesophageal reflux,GER）在未造成任何黏膜或症状的情况下可被认为是正常的生理现象,但造成黏膜的病理改变或出现临床症状时即称为胃食管反流病（gastroesophageal reflux disease,GERD）,可分为食管反流和食管外反流（extra-esophageal reflux）。不论存不存在反流性食管炎,食管外反流症状发生于1/3的GERD成人患者中〔1〕。

Chronic rhinosinusitis（CRS）is a highly prevalent disease,it affects approximately 2%-16% of the adult population.The prevalence of CRS is higher in patients with comorbid diseases,such as asthma,chronic obstructive pulmonary disease,and environmental allergies.The risk factors for chronic rhinosinusitis include genetic mutation,comorbid airway diseases and environmental factors.In recent years,some studies indicated that laryngopharyngeal reflux（LPR）was the potential risk factor for CRS.LPR is a kind of extra-esophageal reflux.The diagnostic criteria for LPR include abnormal reflux symptom index,reflux findings score and ambulatory 24 h double pH-probe monitoring.The pathogenic mechanisms involved in CRS related to LPR remains obscure.Some researches had shown that anti-reflux treatment could improve the syndrome of CRS patients.Further studies are need to explore the relationship between LPR and CRS.