葛根素在抗卵巢抗体阳性卵巢早衰患者中的应用价值与安全性研究

Study of Puerarin-Treatment for Patients with Ao Ab-Positive POF

目的研究葛根素对AoAb阳性POF患者的治疗效果和应用经验,并探索葛根素对于POF患者AoAb的调节机制。方法将确诊为AoAb阳性的POF患者80例随机分为治疗组和对照组各40例,对照组采用雌激素-安宫黄体酮替代治疗,治疗组采用葛根素-安宫黄体酮序贯治疗,比较两组的临床疗效、激素水平、AoAb变化。结果两组治疗后的Kupperman评分与治疗前比较,差异有统计学意义(P<0.05);两组间治疗前后的Kupperman评分均无统计学差异(P>0.05)。两组的治疗效果比较,差异无统计学意义(P>0.05)。与治疗前比较,两组治疗后的FSH、LH水平均有显著降低(P<0.05);治疗组治疗后的E_2无明显变化(P>0.05),对照组治疗后E_2水平显著升高(P<0.05)。治疗组治疗后的AoAb浓度显著低于对照组和治疗前(P<0.05)。未发现葛根素诱发雌激素相关性肿瘤的发生。结论葛根素-安宫黄体酮序贯疗法是治疗POF的一种安全有效的方法,可降低血液AoAb浓度,甚至转阴,进而发挥保护卵巢的作用。

Objective To study the treatment effect and application experience of Puerarin on AoAb-positive POF patients, and to explore the regulation mechanism of Puerarin in AoAb-positive POF patients. Methods Eighty patients diagnosed as AoAb-positive POF were randomly divided into two groups, with 40 cases in each group. The control group was given estrogen-medroxyprogesterone acetate replacement therapy, while the treatment group was given Puerarin-medroxyprogesterone acetate sequential therapy. The clinical efficacy, changes in hormone levels and AoAb concentration were observed and compared. Results The Kupperman scores of both groups after treatment were significantly lower than those before treatment （P〈0.05）, while no statistical difference was found between two groups in the Kupperman score before and after treatment （P〉0.05）. No statistical difference was found between two groups in the treatment efficacy （P 〉0.05）. After treatment, the FSH and LH levels of both groups decreased significantly （P 〈0.05）, the E2 level of control group increased significantly （P〈0.05）, while the E2 level had no significant change in treatment group （P〉0.05）. The AoAb concentration of treatment group after treatment was significantly lower than that before treatment, and that of control group （P 〈0.05）. No Puerarin-induced estrogen-related tumor was found. Conclusions Puerarin-medroxyprogesterone acetate sequential therapy is a safe and effective method to treat POF. It can reduce the blood concentration of AoAb, even make it negative, so as to play the protection effect for ovarian function.