米非司酮治疗子宫肌瘤的用药效果及剂量分析

Analysis on the Effect and Dose of Mifepristone for the Treatment of Uterine Myoma

目的探讨米非司酮治疗子宫肌瘤的用药效果及给药剂量。方法选取我院2013年7月至2015年3月收治的子宫肌瘤患者102例,随机分为两组各51例。常规组给予大剂量米非司酮治疗,实验组给予小剂量米非司酮治疗,比较两组患者的治疗效果。结果治疗后,两组患者的肌瘤体积均明显缩小,与治疗前体积相比差异显著(P<0.05),但组间治疗后的体积无明显差异(P>0.05)。治疗后两组患者的E2与P水平均明显下降(P<0.05),组间比较差异无统计学意义(P>0.05)。实验组患者的不良反应发生率为5.88%,明显低于常规组(P<0.05)。结论相比大剂量给药方式,小剂量米非司酮治疗子宫肌瘤患者的不良反应更少,药物安全性更高。

Objective To explore the effect and dose of mifepristone for the treatment of uterine myoma. Methods A total of 102 cases of patients with uterine myoma admitted to our hospital from July 2013 to March 2015 were selected and randomly divided into two groups, with 51 cases in each group. The routine group was treated with high dose ofmifepristone, while the experimental group was treated with low dose of mifepristone. The curative effects of two groups were compared. Results After treatment, the myoma volume of both groups reduced significantly （P〈0.05）, while no statistical difference was found between two groups （P〉0.05）. After treatment, the levels of E2 and P of both groups decreased significantly （P 〈0.05）, while no statistical difference was found between two groups （P 〉0.05）. The incidence of adverse reactions of experimental group was 5.88%, significantly lower than that of routine group, with statistical difference （P 〈0.05）. Conclusions Compared with high-dose administration, small dose ofmifepristone for the treatment of patients with uterine myoma has fewer adverse reactions, and higher drug safety.