血浆脂蛋白相关磷脂酶A2水平对进展性脑梗死的预测价值研究

Predictive Value of Plasma Lipoprotein-Associated Phospholipase A2 for Progressive Cerebral Infarction

目的探讨血浆脂蛋白相关磷脂酶A2(Lp-PLA2)水平对进展性脑梗死的预测价值。方法收集2014年5月至2015年5月我院收治的68例脑梗死患者作为实验组,另取同期体检的68例健康人群作为对照组,于清晨空腹采集静脉血3 m L,采用ELISA法对血清中Lp-PLA2水平进行测定。比较进展性脑梗死和稳定性脑梗死患者的Lp-PLA2水平,并根据患者的LpPLA2水平划分为四个等级,比较四个等级发生终点事件的情况。结果对照组Lp-PLA2水平明显低于实验组,差异有统计学意义(P<0.05)。稳定性脑梗死患者Lp-PLA2水平低于进展性脑梗死患者,差异有统计学意义(P<0.05)。1组患者终点事件发生率明显低于其他3组,差异均有统计学意义(均P<0.05);2组患者终点事件发生率明显低于4组,差异有统计学意义(P<0.05);3组终点事件发生率明显低于4组,差异有统计学意义(P<0.05)。结论进展性脑梗死患者的Lp-PLA2水平明显更高,可将Lp-PLA2作为进展性脑梗死患者风险评估的预测指标。

Objective To explore the predictive value of plasma lipoprotein-associated phospholipase A2 （Lp-PLA2） for progressive cerebral infarction. Methods A total of 68 cases of patients with cerebral infarction admitted to our hospital from May 2014 to May 2015 were selected as the experimental group, and 68 cases of healthy person at the same period were selected as the control group. ELISA was used to detect the Lp-PLA2 levels of two groups. The Lp-PLA2 level was compared between progressive cerebral infarction patients and steady cerebral infarction patients. According to the Lp-PLA2 level, patients were divided into four degree, and the endpoint events of four degree were compared. Results The Lp-PLA2 level of control group was significantly lower than that of experimental group （P 〈0.05）. Patients with steady cerebral infarction had significantly lower Lp-PLA2 level than patients with progressive cerebral infarction （P 〈0.05）. Patients were divided into four degree, and the incidence ofendpoint event of group 1 was significantly lower than that of the other 3 groups, group 2 was significantly lower than group 4, and group 3 was significantly lower than group 4, all the differences were statistically significant （all P〈0.05）. Conclusions Patients with progressive cerebral infarction have significantly higher Lp-PLA2 level, and Lp-PLA2 can be used as a predictive index for risk assessment of patients with progressive cerebral infarction.