c-Myc启动子结合蛋白1与肿瘤

c-Myc promoter binding protein 1 and tumor

人c-Myc原癌基因启动子结合蛋白1(c-Myc promoter binding protein 1,MBP-1)是新近发现的一个定位于细胞核内的调节分子,能靶向调控多种细胞增殖、凋亡和肿瘤相关基因的表达。本文归纳和总结了其基因结构、细胞定位、调控的下游靶分子及其与肿瘤发生发展的相关性等方面的研究进展。

Human c-Myc promoter binding protein 1（ MBP-1） is a molecule recently discovered located in cell nucleus. MBP-1 can modulate the expressing of multiple genes related to cell proliferation,apoptosis and tumor. This article summarizes the research progress of this molecule,including its gene structure,cellular location,down streaming target molecules and its association to tumor.