过敏性紫癜合并心肌损害141例临床分析

Henoch-Schonlein Purpura with Myocardial Damage in 141 Children

目的探讨小儿过敏性紫癜合并心肌损害的临床特点、发病机制及预后转归等。方法回顾性分析2014年1～12月首都医科大学附属北京儿童医院收治过敏性紫癜合并心肌损害患儿的临床资料，对其辅助检查及治疗转归等进行归纳和分析。结果过敏性紫癜患儿358例，合并心肌损害141例，均有心电图异常改变，其中心律失常135例，心肌酶谱异常9例，超声心动图异常2例。9例患儿有胸闷憋气、心悸、心前区不适等表现。141例经常规治疗及保心肌治疗1～4周后心电图恢复正常134例。结论小儿过敏性紫癜合并心肌损害临床常见，心肌损害症状少，以心电图异常多见，预后好。

Objective To investigate the clinical characteristics,pathogenesis and prognosis of Henoch - Schnolcin purpura（HSP） children with myocardial damage. Methods All clinical data of HSP patients with myocardial damage admitted to Beijing Children＇s Hospital Affiliated to Capital Medical University, from Jan. 2014 to Dec. 2014 were reviewed. Their laboratory examinations, treatments and prognosis were analyzed. Results There were 141 patients with myocardial damage in all 358 HSP patients,and all of the 141 patients had abnormal changes of Electrocadiogram （ECG）. Among them, 135 cases had arrthymia,9 cases were abnormal myocardial enzymes, and 2 cases had abnomal echocardiography. 9 cases had shortness of breath,palpitation,precordial discomfort and so on. of 141 cases treated with conventional therapy and the treatment of myocardial protection, after i - 4 weeks, 134 cases＇ ECG returned to normal. Conclusion HSP with myocardial damage in children were common,the symptom of cardiac muscle damage were mild,the abnormal of ECG were common, the prognosis were good.