甲状腺滤泡癌中PPARγ的表达及其临床病理学意义

Expression of PPARγ in follicular thyroid carcinoma and its clinicopathological significance

目的·探讨甲状腺滤泡性肿瘤中PPARγ的表达。方法·收集近2年保存的194例甲状腺滤泡性肿瘤标本,采用免疫组织化学En Vision法进行PPARγ表达的检测。其中滤泡癌60例,良性腺瘤80例,非典型腺瘤54例。结果·PPARγ的表达水平在良性腺瘤、非典型腺瘤和滤泡癌中逐渐升高。PPARγ强阳性表达在滤泡癌与良性腺瘤之间、非典型腺瘤与良性腺瘤之间差异均有统计学意义,而在滤泡癌与非典型腺瘤之间差异无统计学意义。结论·PPARγ是甲状腺滤泡癌比较特异的免疫标志物,对滤泡癌的诊断具有重要提示作用。

Objective·To explore the expression of peroxisome proliferator activated receptor γ（PPARγ） in follicular-patterned thyroid tumors. Methods·Follicular-patterned thyroid tumor samples from 194 cases that were diagnosed in recent two years were collected, including 60 cases of follicular carcinoma, 80 cases of benign adenoma, and 54 cases of atypical adenoma. The expression of PPARγ was measured by immunohistochemical staining （EnVision method）. Results·The expression level of PPARγ gradually increased from benign adenoma to atypical adenoma and follicular carcinoma. The differences in strong positive PPARγ expression between follicular carcinoma and benign adenoma, and atypical adenoma and benign adenoma were statistically significant, while the difference between follicular carcinoma and atypical adenoma was not statistically significant. Conclusion·PPARγ is a specific immune marker for follicular carcinoma and important in the diagnosis of follicular carcinoma.