慢性肾脏病患者肾性贫血相关因素及中医学研究

Chronic Kidney Disease Patients with Renal Anemia Related Factors and Traditional Chinese Medicine Research

目的：探讨慢性肾脏病（CKD）患者肾性贫血（renal anemia,RA）相关因素及中医证候特点。方法：130例CKD3-5期住院患者进行研究,收集贫血、肾功能等临床资料,进行中医证候辨证;将130例CKD3-5期并RA患者根据e GRF分为3组,应用方差分析比较各组间差异,多元回归法分析肾性贫血的相关影响因素。结果：随着e GFR下降,血红蛋白、血清铁指标,P值均〈0.05,差异有统计学意义;多元回归提示血红蛋白下降与肾功能进展呈正相关。肾性贫血患者的中医病机为本虚标实、气血阴阳亏虚;本虚证以阴阳两虚证比例最高（30.1%）,标实证以湿毒最高（26.4%）。结论：CKD患者肾性贫血程度与e GRF下降呈正相关。中医病机以阴阳两虚证、湿毒症最多见,值得临床加以关注。

Objective：To analyze the chronic kidney diseases renal anemia related factors and its association with Traditional Chinese Medicine（TCM） syndrome. Methods：According to eGRF. The 130 C KD3 - 5 and RA patients into three groups, application of variance analysis and comparison between groups. Then used multiple regression analysis to analyze related factors with the renal anemia. Results： With the decline of eGFR, Hemoglobin, and serum iron P 〈 0.05, has statistical significance. Renal anemia in patients with the pathogenesis of TCM for this virtual to qi and blood, Yin and Yang deficiency. Yin and yang in percentage （30.1% ）, wet poison in percentage （26.4%）. Conclusion：With eGFR decline, renal anemia in CKD patients positively correlated. These patients TCM pathogenesis both Yin and Yang deficiency syndrome, wet poison are more occurred, are deserved us attention.