高血压患者血中Hcy与颈动脉斑块的相关性分析

目的：通过检测高血压患者血中同型半胱氨酸（Hcy）浓度，分析Hcy与颈动脉斑块的相关性。方法选取2012年8月至2015年7月治疗的102例高血压病2~3级的患者。将行颈动脉超声检查有颈动脉斑块的48例设为颈动脉斑块组，根据颈动脉斑块的严重程度将患者分成轻度狭窄、中度狭窄及重度狭窄三个亚组；将行颈动脉超声检查无颈动脉斑块的54例设为对照组。比较两组之间和各亚组之间血液中Hcy值。结果颈动脉斑块组与对照组血液中Hcy比较差异有统计学意义（P〈0.05）。Hcy水平随颈动脉狭窄程度增加有明显升高的趋势。结论高血压病患者血液中Hcy浓度与颈动脉斑块有显著相关性。

ObjectiveThrough detecting the concentration of homocysteine in the blood of the hypertensive patients,to analyze their correlation with carotid artery plaque.MethodsSelected 102 hypertensive patients（hypertension grade2 to 3）in the cardiovascular department of our hospital from August 2012 to July 2015. The neck vascular ultrasound findings of carotid plaque in 48 cases as carotid artery plaque group,according to the degree of impact on vascular patients were divided into three subgroups：mild stenosis,moderate stenosis,severe stenosis;54 cases were not found carotid plaque by cervical vascular ultrasound as control group.Compared Hcy value in the blood between the two groups and each subgroups. ResultsHcy of blood among the carotid artery plaque group and the control group were significantly different（P〈0.05）.Hcy level was significantly increased with the increasing trend of the degree of carotid stenosis.ConclusionAmong hypertensive patients,Hcy concentration and carotid plaque were positively correlative.