ADAM17在胃癌中的表达及意义

目的：探讨去整合素金属蛋白酶17（ADAM17）在胃癌中的表达及意义。方法采用免疫组织化学方法检测胃癌组织中ADAM17的表达，并分析ADAM17表达与胃癌临床病理特征之间的关系，同时观察ADAM17表达与HER-2、VEGF表达的关系。结果 ADAM17在胃癌组织中表达阳性率为15.1%，两组在年龄、性别、肿瘤位置、临床分期、分化程度的差异无统计学意义（P〉0.05），浸润深度、脉管侵犯、淋巴结转移的差异有统计学意义（P〈0.05）。ADAM与VEGF表达差异具有统计学意义（P〈0.05），而ADAM与Her-2的表达差异不具有统计学意义（P〉0.05）。结论 ADAM17在胃癌中的表达与局部浸润、淋巴结转移、脉管侵犯有关，是预后不良的有效指标。

ObjectiveDiscussion disintegrin metalloprotease 17（ADAM17）expression and significance in gastric cancer. MethodsImmunohistochemical method to detect the expression of ADAM17 in gastric cancer tissues.Analyze the relationship between ADAM17 expression and clinicopathological features of gastric cancer.While observing ADAM17,HER-2,VEGF expression.ResultsADAM17 expression was 15.1% in gastric cancer.No signifi cant difference between the two groups in age,sex,tumor location,clinical stage,degree of differentiationwere found（P〉0.05）. Depth of invasion,vascular invasion,lymph node metastasis were signifi cantly different（P〈0.05）.ADAM and VEGF expression had significant difference（P〈0.05）,whereas the expression of ADAM and Her-2 does not have a statistically significant difference（P〉0.05）. ConclusionsADAM17 expression in gastric cancer with infi ltration,lymph node metastasis,vascular invasion related,is an effective indicator of poor prognosis.