期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

脑源性神经营养因子基因甲基化在抑郁症中的研究进展 被引量：4

下载PDF
导出
摘要 脑源性神经营养因子(brain derived neurotrophic factor,BDNF)作为情绪障碍的一个重要的功能候选基因,在抑郁症的发生发展中具有重要作用。环境因素通过影响BDNF基因表观遗传学修饰调控基因的转录与表达从而参与抑郁症的病理生理学机制。DNA甲基化作为最常见的表观遗传调控方式,在抑郁症的病因中占有重要角色。近年有研究发现,BDNF基因甲基化能通过调控基因的转录与表达,进而与抑郁症的患病率和发病率以及抑郁症状的严重程度有关。探讨BDNF基因甲基化在了抑郁症中的作用,很可能为研究BDNF基因在抑郁症病因机制中所扮演的角色及抑郁症的治疗提供了新的思路。
作者 孙亭 李广学 高树贵
机构地区 宁波大学医学院
出处 《临床荟萃》 CAS 2016年第10期1151-1154,共4页 Clinical Focus
基金 浙江省医药卫生科技项目(2015KYB351) 宁波市自然科学基金资助项目(2015A610196)
关键词 抑郁症 脑源性神经营养因子 甲基化
分类号 R749.42 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献23

  • 1Fuchikami M, Morinobu S, Segawa M, et al. DNAmethylation profiles of the brain-derived neurotrophie factor (BDNF) gene as a potent diagnostic biomarker in major depression[J]. PLoS One, 2011, 6(8):e23881.
  • 2Murray CJ, Vos T, Lozano R, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010[J]. Lancet, 2012, 380(9859):2197-2223.
  • 3Lee BH, Kim YK. The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment [J]. Psychiatry Investig, 2010, 7(4) :231-235.
  • 4Cheng J, Wang Y, Zhou K, et al. Male-specific association between dopamine receptor D4 gone methylation and schizophrenia[J]. PLoS One, 2014, 9(2):e89128.
  • 5Mill J, Tang T, Kaminsky Z, et al. Epigenomic profiling reveals DNA-methylation changes associated with major psychosis[J]. Am J Hum Genet, 2008, 82(3) :696-711.
  • 6Dwivedi Y, Rizavi HS, Conley RR, etal. Altered gene expression o[ brain-derived neurotrophic fac~tor and reeep~tor tyrosine kinase B in postmortem brain of suicide subjects[J]. Arch Gen Psychiatry, 2003, 60(8) : 804-815.
  • 7Dennis KE, Levitt P. Regional expression of brain derived neurotrophic factor (BDNF) is correlated with dynamic patterns of promoter methylation in the developing mouse forebrain[J]. Brain Res Mol Brain Res, 2005, 140(1-2) :1-9.
  • 8梁炜,张红梅,张红亚,吕路线.抑郁症患者脑源性神经营养因子蛋白及基因表达水平与自杀行为的关联分析[J].中国心理卫生杂志,2012,26(10):726-730. 被引量：19
  • 9Karege F, Perret G, Bondolfi G,et al. Decreased serum brain- derived neurotrophic factor levels in major depressed patients [J].Psychiatry Res, 2002, 109(2) : 143-148.
  • 10Munno D, Sterpone S, Fania S, et al. Plasma brain derived neurotrophic factor levels and neuropsychological aspects of depressed patients treated with paroxetine[J]. Panminerva Med, 2013, 55(4):377-384.

二级参考文献17

  • 1汤毓华.汉密顿抑郁量表.中国心理卫生杂志,1999,12.
  • 2中华医学会精神科分会.中国精神障碍分类与诊断标准第3版(CCMD-3)[M].济南:山东科学技术出版社,2001.91-103.
  • 3Jaeschke R, Siwek M, Dudek D. Neurobiology of suicidal behav- iour [ J]. Psychiatr Pol, 2011,45(4) : 573 - 588.
  • 4Sher L. Preventing suicide [ J]. QJM, 2004, 97 (10) : 677 - 680.
  • 5Sher L. Brain-derived neurotrophic factor and suicidal behavior [ J]. QJM, 2011, 104 (5) : 455 - 458.
  • 6Pandey GN, Dwivedi Y, Rizavi HS. Brain-derived neurotrophic fac- tor gene and protein expression in pediatric and adult depressed subjects [J]. Prog Neuropsychopharmacol Biol Psychiatry, 2010, 34(4):645 -651.
  • 7夏朝云.自杀意念自评量表[J].中国行为医学科学,2001,10(特刊):285-286.
  • 8Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2-△△C ACt Method [ J]. Methods, 2001,25(4) : 402 - 408. Pan W, Banks WA, Fasold MB. Transport of brain-derived neuro- trophic factor across the blood-brain barrier [ J]. Neuropharmacolo- gy, 1998, 37(12) : 1553 - 1561. Kerschensteiner M, Gallmeier E, Behrens L. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? [ J]. J Exp Med, 1999, 189(5) : 865 - 870. Lee BH, Kim YK. BDNF mRNA expression of peripheral blood mononuclear cells was decreased in depressive patients who had or had not recently attempted suicide [J]. J Affect Disord, 2010, 125 ( 1 - 3) : 369 - 373. Cattaneo A, Bocchio-Chiavetto L. Reduced peripheral brain-derived neurotrophic factor mRNA levels are normalized by antidepressant treatment [J]. Int J Neuropsychopharmacol, 2010, 13 ( 1 ) : 103 - 108.
  • 9Pan W, Banks WA, Fasold MB. Transport of brain-derived neuro- trophic factor across the blood-brain barrier [ J]. Neuropharmacolo- gy, 1998, 37(12) : 1553 - 1561.
  • 10Kerschensteiner M, Gallmeier E, Behreus L. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? [ J]. J Exp Med, 1999, 189(5) : 865 - 870.

共引文献18

同被引文献71

引证文献4

二级引证文献46

临床荟萃
2016年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部